New vascular insights into premature aging

New vascular insights into premature aging - PubMed

Hutchinson-Gilford progeria syndrome (HGPS) is a fatal disease characterized by premature aging in which young children fail to thrive and adolescents die ...

New vascular insights into premature aging - JCI

In this issue of the JCI, Osmanagic-Myers and colleagues identify the cellular mechanisms that lead to vascular abnormalities and death in children with HGPS.

New vascular insights into premature aging - PMC - NCBI

The current new studies reveal novel insights into accelerated atherosclerosis in HGPS. Progerin in the vascular wall drives the cardiovascular ...

New vascular insights into premature aging - JCI

However, in endothelial cells of subjects with Hutchinson-Gilford progeria syndrome, the mutant lamin called progerin interferes with normal ...

New vascular insights into premature aging - Johns Hopkins University

AB - Hutchinson-Gilford progeria syndrome (HGPS) is a fatal disease characterized by premature aging in which young children fail to thrive and ...

[PDF] New vascular insights into premature aging. | Semantic Scholar

The cellular mechanisms that lead to vascular abnormalities and death in children with HGPS are identified and identified in this issue of the JCI.

New insights into vascular aging: Emerging role of mitochondria ...

Mitochondria play an important role in vascular aging. In endothelial and smooth muscle cells, multiple changes in the mitochondrial structure and function ...

'Paving the way' for improved treatment of premature aging disease

Published in the journal Aging Cell on October 18, 2024, in collaboration with researchers from the National Institutes of Health (NIH) and Duke ...

Organ-on-a-Chip Model Offers Insights into Premature Aging and ...

HGPS primarily affects vascular cells, which undergo biomechanical strains in blood vessels. However, the impact of these biomechanical strains ...

Molecular Mechanisms of Vascular Health - AHA Journals

Vascular aging is a biological variable, conceptually distinct from chronological aging, whereby sequential and progressive changes in a cell or ...

New vascular insights into premature aging - OUCI

New vascular insights into premature aging. https://doi.org/10.1172/jci125616 ... List of references. Baker, Cardiovascular abnormalities in progeria.

Organ-on-a-chip model offers insights into premature aging ...

Using a new progeria-on-a-chip model, investigators have developed a way to recapitulate blood vessel dynamics to better understand vascular ...

Irisin: A Potentially Fresh Insight into the Molecular Mechanisms ...

Vascular aging refers to age-related changes in blood vessels. These changes can increase the risk of developing cardiovascular diseases, such as hypertension, ...

Understanding Vascular Diseases: Lessons From Premature Aging ...

Premature aging syndromes are extremely rare genetic disorders that exhibit clinical phenotypes resembling accelerated aging, including severe atherosclerosis.

Aging and aging-related diseases: from molecular mechanisms to ...

It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including ...

Vascular smooth muscle cell aging: Insights from Hutchinson-Gilford ...

Because experiments with mouse models have demonstrated that alterations in VSMCs are responsible for early atherosclerosis in HGPS, studies on this disease can ...

Accelerated Early Vascular Aging Among Adolescents With Obesity ...

The normal rate of subclinical vascular aging from adolescence to young adulthood has not been well‐characterized.

The NRF2/ID2 Axis in Vascular Smooth Muscle Cells: Novel Insights ...

Using a chronologically aging mouse model, we noted a significant decline in the expression of NRF2 in the aged mice aortas, coinciding with increased VC.

Translational Science in Vascular Aging: From Bench to Bedside ...

The industry's interest in vascular aging underscores the potential for novel markers to drive better patient outcomes in cardiovascular ...

Vascular smooth muscle cell aging: Insights from Hutchinson-Gilford ...

... in premature vascular aging. HGPS is a rare genetic disorder characterized ... Splicing-directed therapy in a new mouse. 49. Page 9. M.R. Hamczyk and R.M. ...