Not only tumor but also therapy heterogeneity

Not only tumor but also therapy heterogeneity - Annals of Oncology

Next-generation clinical trials: novel strategies to address the challenge of tumor molecular heterogeneity

Not only tumor but also therapy heterogeneity - PubMed

Not only tumor but also therapy heterogeneity.

Not only tumor but also therapy heterogeneity - Annals of Oncology

Components of the tumor microenvironment (TME) are heter- ogeneous too, and contribute to the inter- and intratumor diversity of cancer cells.

Tumor heterogeneity and the dilemma of antioxidant therapies in ...

Intra-tumor heterogeneity (ITH) consists of subpopulations of cancer cells within a tumor with different phenotypic, genetic and behavioral characteristics, ...

Tumor microenvironment heterogeneity an important mediator of ...

Tumor heterogeneity has been a major contributor to lethal outcomes, drug resistance, and therapeutic failures, and presents a key challenge to precision ...

What Is Tumor Heterogeneity? | Memorial Sloan Kettering Cancer ...

One implication is that more-sophisticated tools will be needed to characterize patients' cancers and guide their treatment. Pathological ...

Heterogeneity of hepatocellular carcinoma: from mechanisms to ...

Intratumoral heterogeneity is an important aspect of the spectrum of complex tumor heterogeneity and contributes to late diagnosis and treatment ...

Tumor Heterogeneity and Therapeutic Resistance

Molecular variabilities, or tumor intrinsic properties, are not the only source of tumor heterogeneity. Extrinsic properties of the tumor cell—including ...

A narrative review of tumor heterogeneity and challenges to tumor ...

Tumor heterogeneity and drug resistanceOther Section ... In terms of composition, solid tumors include not only cancer cells, but also ...

Tumour Heterogeneity - an overview | ScienceDirect Topics

Tumor heterogeneity is one of the characteristics of malignant tumors and refers to the biological or genetic alteration of daughter cells as a result of ...

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

Cellular phenotypic heterogeneity within tumors is a complex, multifactorial phenomenon, which integrates genetic, epigenetic, and environmental ...

Tumor heterogeneity reshapes the tumor microenvironment to ...

Drug resistance caused by tumor heterogeneity exists across all cancer types and all therapeutic modes, including chemotherapy, radiotherapy, targeted therapy, ...

Heterogeneity and Cancer

Intrapatient tumor heterogeneity presents multiple clinical challenges, from the initial diagnosis to the treatment of metastatic disease. At ...

Clinical implications of intratumor heterogeneity: challenges and ...

Tumor heterogeneity has presented a considerable challenge to matching patients with the right treatment at the right time; therefore, it poses ...

Tumor Heterogeneity: A Great Barrier in the Age of Cancer ... - MDPI

Patients acquire mutations not only in different genes, but also in different domains within the same gene [12]. Heterogeneity is also prevalent ...

Overview on Clinical Relevance of Intra-Tumor Heterogeneity

In particular, intra-tumor heterogeneity (ITH) is closely related to cancer progression, resistance to therapy, and recurrences. It is interconnected with ...

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

of clinical resistance is likely to involve not only ... Darwinian dynamics of intratumoral heterogeneity: not solely · random mutations but also ...

Modeling genetic heterogeneity of drug response and resistance in ...

Heterogeneity in cancer refers to the many ways that tumors can vary between and within patients [1]. Within an individual, intertumor heterogeneity describes ...

Tumour Heterogeneity: The Key Advantages of Single-Cell Analysis

Furthermore, intra-tumour heterogeneity applies not only to tumour cells, but also to the components of their microenvironment [8]. The cancer cell ...

Emerging insights of tumor heterogeneity and drug resistance ...

The identification of actionable oncogenic mutations has greatly improved the treatment of various human cancers, as evident by the development ...