Notch1 is a target of miR|34c|5p.

miR-34c-5p targets Notch1 and suppresses the metastasis and ...

In gastric cancer, miR-34c-5p was revealed to directly bind to the 3′UTR of the microtubule-associated protein tau (MAPT) and inhibit the ...

miR‑34c‑5p targets Notch1 and suppresses the metastasis and ...

The present study concluded that miR‐34c‐5p was a tumor suppressor in CC and may be a novel measure for the future treatment of CC.

miR‑34c‑5p targets Notch1 and suppresses the metastasis and ...

Molecular Medicine Reports · miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer.

Notch1 is a target of miR-34c-5p. (A) The 3'-UTR of Notch1 mRNA...

Luciferase activity was analyzed after 24 h of transfection. (C) mRNA expression levels of Notch1 were determined in HeLa cells (D and E) The protein expression ...

The NOTCH1 and miR-34a signaling network is affected by TP53 ...

In chronic lymphocytic leukemia (CLL), TP53 mutations or deletions on chromosome 17p lead to adverse prognosis and reduced levels of miR-34a, which targets ...

MiR-34c represses muscle development by forming a regulatory ...

Notch1 signal pathway regulates the transcription of certain types of miRNAs which further affects target gene expression. However, the specific ...

The interaction between miRNAs/lncRNAs and Notch pathway in ...

The interplay between Notch1 and miR-19 has been shown to be involved in ... A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell ...

miRNA 34c Suppresses Osteosarcoma Progression In Vivo by ...

Mechanistically, we confirmed that miR 34c directly targets the 3′ untranslated region (3′UTR) of multiple components of Notch signaling (Notch1, Notch2, and ...

Notch signaling pathway in cancer: from mechanistic insights to ...

Huang and colleagues uncovered that Notch1 negatively regulates miR ... Myc is a Notch1 transcriptional target and a requisite for Notch1-induced ...

Notch1 in Cancer Therapy: Possible Clinical Implications and ...

These include Notch1 monoclonal antibodies, Notch1 decoy, Notch1 siRNA, Notch1 microRNA (miRNA), natural products, anti-DLL4 antibodies, α- ...

circAGTPBP1 promotes the progression of papillary thyroid cancer ...

Using RNA-seq and bioinformatic analysis, we identified miR-34a-5p and NOTCH1 as downstream targets of circAGTPBP1. Functionally, circAGTPBP1 ...

MicroRNA‑34a inhibits the proliferation and promotes the ...

Collectively, the present results suggested that miR‑34a may negatively regulate Notch1 expression and may be a potential therapeutic target for ...

MicroRNA-34a suppresses invasion through downregulation of ...

Transient forced expression of miR-34a did not affect the proliferation of these cell lines. Computational miRNA target prediction suggested that Notch1 and ...

Notch1 pathway-mediated microRNA-151-5p promotes gastric ...

Then Notch receptor intracellular domains are translocated into nucleus to activate expression levels of target genes via both C promoter ...

miR-34c-5p targets Notch1 and suppresses the - ProQuest

miR-34c-5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer. Wei, Huali; Wang, Xiaolan; Niu, Xiumin; Jiao, Ruili; Li, Xiaojuan ...

MicroRNA-34a targets notch1 and inhibits cell proliferation in ...

Overexpression of miR-34a could induce apoptosis of glioblastoma cells. Also, we identified notch1 as a direct target gene of miR-34a. Knockdown of notch1 ...

Targeting the Notch1 oncogene by miR-139-5p inhibits glioma ...

Notch1 was upregulated in classical and proneural subtypes of GBM, and associated with tumour grade. Notch1 inhibition suppressed the biological ...

NOTCH1 | Cancer Genetics Web

MTDH, SKP2, BCL9, and NOTCH1 genes were overexpressed in ovarian cancer cells, and they are direct target genes of miR-30a-5p. miR-30a-5p overexpression ...

MiR-137 inhibits cervical cancer progression via down-modulating ...

MiR-137 targets Notch1 and regulates CC through the PI3K/Akt/mTOR pathway. The miR-137/Notch1 axis may be a promising target for CC patients.

Repression of tumor suppressor miR-451 is essential for NOTCH1 ...

We identified the Myc oncogene as a potential target of both miRNAs, and the Akt and Ras-GRF1 oncogenes as potential targets of miR-709 (Fig. 2 A). Myc is known ...