Novel Therapeutics for Neonatal Seizures

Novel Therapeutics for Neonatal Seizures - PMC - PubMed Central

Despite some efficacy demonstrated by levetiracetam, this study provides strong evidence of the superiority of phenobarbital as a first-line antiseizure ...

Novel Therapeutics for Neonatal Seizures - PubMed

Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and ...

Ganaxolone: A New Treatment for Neonatal Seizures - Frontiers

In this mini-review, we present evidence in support of the use of ganaxolone, a GABAA agonist neurosteroid, as a novel neonatal therapy. We discuss evidence ...

A novel approach to seizures in neonates - ScienceDirect

Treatment of neonatal epilepsies ... Neonates with epilepsy usually require a personalized, etiology-based approach in terms of choice and duration of treatment.

Neonatal seizures: Closing the knowledge and treatment gap

Only one drug—phenobarbital—is approved for treating neonatal seizures. Effective in only 30% to 40% of cases, the drug may extinguish the clinical signs of ...

Neonatal Seizures: New Evidence, Classification, and Guidelines

Therapeutic hypothermia may reduce seizure burden in term neonates with hypoxic-ischemic encephalopathy. However, the impact of therapeutic ...

Neonatal seizures: A promising new drug - Boston Children's Answers

Over the past decade, research led by Soul has supported use of a completely new seizure treatment — one that's tailored to newborns' uniquely ...

Recommendations for the design of therapeutic trials for neonatal ...

There is increasing interest in conducting trials of novel drugs to treat neonatal seizures, but the unique characteristics of this disorder and ...

Neonatal Seizures | NeoReviews | American Academy of Pediatrics

(65) The authors suggest that the new findings support discontinuation of ASM before discharge for all newborns after successful treatment ( ...

Treatment of seizures in the neonate: Guidelines and consensus ...

Eleven studies were included (Table S2a) assessing phenobarbital, phenytoin, and levetiracetam as first-line treatment for neonatal seizures.

Novel Therapeutics for Neonatal Seizures | Request PDF

... According to 2011 guidelines on neonatal seizures [33, 49] , phenobarbital (PHB) remains the most commonly used agent for first-line treatment ...

Treatment of Neonatal Seizures: Comparison of ... - ScienceDirect.com

Third-line ASMs were most commonly fosphenytoin or levetiracetam, with alternatives including topiramate or lacosamide. All pathways provided escalation to ...

Novel Therapeutics for Neonatal Seizures - OUCI

Alix V, James M, Jackson AH, et al. Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital. J Child ...

Neonatal seizures—diagnostic options and treatment ...

Acute treatment should aim at stopping both electroclinical and electrographic-only seizures. In neonates with acute provoked seizures, ASM ...

Treatment of Seizures in the Neonate: Guidelines and Consensus ...

However, their enthusiasm for phenobarbital as a first-line ASM (recommendation 1) and treatment of all neonatal seizures including electrographic-only seizures ...

Mechanism-Based Treatment for Neonatal Seizures: Still on the ...

One trial was a dose-finding open-label phase 1/2 trial (NCT01434225, called “NEonatal seizures with Medication Off-patent) conducted in 8 ...

Levetiracetam versus Phenobarbital for Neonatal Seizures

Overall, seizure control had been obtained in 59 (55%) of neonates following first- and second-line therapy with LEV and PB. ASM, antiseizure ...

Levetiracetam Versus Phenobarbital for Neonatal Seizures

This phase IIb randomized controlled trial demonstrates greater efficacy of phenobarbital than levetiracetam in the treatment of neonatal ...

Complex spectrum of phenobarbital effects in a mouse model of ...

Phenobarbital remains the first line drug therapy for the treatment of suspected neonatal seizures ... Novel Therapeutics for Neonatal Seizures.

Neonatal Seizure Registry Publications - UCSF

Parent Mental Health and Family Coping over Two Years after the Birth of a Child with Acute Neonatal Seizures- December 2021 · Seizure Severity and Treatment ...