Novel non|immunogenic trained immunity inducing small molecule ...

Novel non-immunogenic trained immunity inducing small molecule ...

This study introduces a novel small molecule, A1155463, that can induce trained immunity in immune cells called macrophages without triggering ...

High-throughput screen identifies non inflammatory small molecule ...

While one endogenous mineralocorticoid has been shown to induce trained immunity, the induction of innate immune training by glucocorticoids was both unique and ...

Novel non-immunogenic trained immunity inducing small molecule ...

A1155463 training improved anti-tumor resistance to B16.F10 melanoma cells. The effect was enhanced upon combination with checkpoint therapy. In ...

High-throughput screen identifies non inflammatory small molecule ...

We identified over two dozen small molecules in several chemical classes that induce a training phenotype in the absence of initial immune activation.

High-throughput screen identifies non inflammatory small ... - PNAS

Few molecules induce trained immunity; we report the identification of dozens of small molecule inducers of trained immunity identified through ...

GSE270608 - GEO Accession viewer

To identify novel small molecule inducers of trained immunity, we screened a library of 2000 drugs and drug-like compounds. Identification of ...

Trained innate immunity: Concept, nomenclature, and future ...

Furthermore, novel trained immunity–inducing drugs, spanning from the discovery and development of small molecules with modulatory effects ...

Trained immunity — basic concepts and contributions to ... - Nature

This concept originated in the field of infectious diseases — training of innate immune cells, such as monocytes, macrophages and/or natural ...

Small molecules induce trained immunity, opening a new approach ...

A University of Chicago Pritzker School of Molecular Engineering (PME) team has found several small molecule candidates that induce this trained immunity.

Small-molecule screening identifies Syk kinase inhibition and ...

Stimulation with such “innate immune training” molecules imparts an epigenetic memory on the promoters and enhancers of pro-inflammatory ...

High-throughput screen identifies non inflammatory small molecule ...

We identified over two dozen small molecules in several chemical classes that induce a training phenotype in the absence of initial immune activation—a current ...

Trained immunity as a novel therapeutic strategy - ScienceDirect.com

Enhanced immune responses induced by trained immunity, as reflected by an increased interleukin (IL)-6, IL-1β, and tumor necrosis factor α (TNFα) ...

Novel non-immunogenic trained immunity inducing small molecule ...

Article "Novel non-immunogenic trained immunity inducing small molecule with improved anti-tumor properties" Detailed information of the J-GLOBAL is an ...

Trained Immunity Carried by Non-immune Cells - Frontiers

... immunological memory. O'Leary et al. showed that a hapten (small molecule triggering an immune response) (Erkes and Selvan, 2014) induced ...

Defining trained immunity and its role in health and disease - Nature

Conversely, the phenomenon called 'LPS tolerance', which can be induced by low doses of lipopolysaccharide (LPS) and other Toll-like receptor ...

Trained Immunity-Promoting Nanobiologic Therapy Suppresses ...

Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct ...

Trained immunity: General and emerging concepts - Vuscan - 2024

Further early examples of the protective effects induced by innate immune training include CpG oligodeoxynucleotide priming which protects ...

Trained immunity in monocyte/macrophage: Novel mechanism of ...

Trained immunity is mediated via epigenetic and metabolic reprogramming and occurs in mature innate immune cells and their bone marrow progenitors. Natural ...

Induction of Trained Immunity by Recombinant Vaccines

Novel non-immunogenic trained immunity inducing small molecule with improved anti-tumor properties · Medicine, Biology. bioRxiv · 2024.

Trained immunity is regulated by T cell-induced CD40-TRAF6 ...

ously shown to efficiently facilitate drug delivery to myeloid cells but not adaptive immune cells. ... Discovery of small molecule CD40–TRAF6 ...