- O|GlcNAcylation in health and neurodegenerative diseases🔍
- O|GlcNAcylation and Its Roles in Neurodegenerative Diseases🔍
- O|GlcNAcylation and neurodegeneration🔍
- Understanding and exploiting the roles of O|GlcNAc in ...🔍
- JBC Reviews Understanding and exploiting the roles of O|GlcNAc in ...🔍
- Protective Roles of O‐GlcNAc in Neurodegenerative Diseases🔍
- Loss of O|GlcNAc glycosylation in forebrain excitatory neurons ...🔍
- Mechanistic roles for altered O|GlcNAcylation in neurodegenerative ...🔍
O|GlcNAcylation in health and neurodegenerative diseases
O-GlcNAcylation in health and neurodegenerative diseases - Nature
In addition, the status of O-GlcNAcylation in these proteins is associated with many pathological conditions in neurodegenerative diseases. In ...
O-GlcNAcylation and Its Roles in Neurodegenerative Diseases
The common characteristic of these disorders is the aggregation of abnormal proteins in the brain. Current research has found that O-GlcNAcylation dysregulation ...
O-GlcNAcylation and neurodegeneration - PMC - PubMed Central
Increased O-GlcNAcylation has been shown to enhance non-amyloidogenic pathway and inhibit the amyloidogenic pathway, thus providing neuroprotection. In addition ...
Understanding and exploiting the roles of O-GlcNAc in ...
O-GlcNAc is denoted by a blue square. ACD, α-crystallin domain; AD, Alzheimer's disease; IPV, Ile–Pro–Val; NDD, neurodegenerative disease; PD, ...
O-GlcNAcylation and Its Roles in Neurodegenerative Diseases
As a non-classical post-translational modification, O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is widely found ...
O-GlcNAcylation in health and neurodegenerative diseases
O-GlcNAcylation is a posttranslational modification that adds O-linked β- N -acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins.
JBC Reviews Understanding and exploiting the roles of O-GlcNAc in ...
Here, we discuss the features of O-GlcNAc in neurodegenerative diseases, the application of inhibitors to identify the roles of this modification, and the ...
Protective Roles of O‐GlcNAc in Neurodegenerative Diseases
Moreover, pharmacological agents that increase O-GlcNAc levels in the brains of various transgenic models of Alzheimer Disease (AD) strikingly ...
O-GlcNAcylation in health and neurodegenerative diseases
Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the ...
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons ...
O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associated with neurodegenerative diseases ...
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative ...
Importantly, proteins that were found to have decreased O-GlcNAcylation have roles in axonal polarity, membrane integrity, and synaptic health — again ...
O-GlcNAcylation in health and neurodegenerative diseases
Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the manipulation of ...
O-GlcNAc and neurodegeneration: biochemical mechanisms and ...
O-GlcNAc is notably abundant within brain and is present on hundreds of proteins including several, such as tau and the amyloid precursor ...
O-GlcNAc cycling: Implications for neurodegenerative disorders
O-GlcNAcylation impacts transcription, translation, organelle trafficking, proteasomal degradation and apoptosis. O-GlcNAcylation has been implicated in the ...
O-GlcNAc Modification Protects against Protein Misfolding and ...
O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease. Click to copy article linkArticle link ...
O-GlcNAcylation and Its Roles in Neurodegenerative Diseases
The common characteristic of these disorders is the aggregation of abnormal proteins in the brain. Current research has found that O- ...
O-GlcNAc forces an α-synuclein amyloid strain with notably ... - Nature
1a), has been linked to several biological processes, including protein aggregation and neurodegeneration in several NDDs. For example, O-GlcNAc ...
O-GlcNAcylation in health and neurodegenerative diseases
O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins.
O-GlcNAcylation in health and neurodegenerative diseases.
Detailed Record ; Title: O-GlcNAcylation in health and neurodegenerative diseases. ; Language: English ; Authors: Lee, Byeong Eun1 (AUTHOR) Suh, Pann-Ghill1,2 ( ...
O-GlcNAcylation and Its Roles in Neurodegenerative Diseases
Abstract. As a non-classical post-translational modification, O-linked -N-acetylglucosamine (O-GlcNAc) modification.