O|GlcNAcylation in tumorigenesis and its implications for cancer ...

O-GlcNAcylation in tumorigenesis and its implications for cancer ...

Cells respond to extracellular and intracellular cues through diverse signaling pathways, and those signals are usually dysregulated in cancer ...

O-GlcNAcylation in tumorigenesis and its implications for cancer ...

O-GlcNAcylation plays an important role in tumorigenesis and progression through the modification of specific protein substrates.

O-GlcNAcylation and Its Role in Cancer-Associated Inflammation

Cancer cells, as well as surrounding stromal and inflammatory cells, form an inflammatory tumor microenvironment (TME) to promote all stages of carcinogenesis.

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA.

O-GlcNAcylation: A New Cancer Hallmark? | Endocrinology - Frontiers

As a nutrient sensor, O-GlcNAcylation can relay the effects of excessive nutritional intake, an important cancer risk factor, on protein ...

The essential role of YAP O-GlcNAcylation in high-glucose ... - Nature

Pathologically, aberrant O-GlcNAcylation has been shown to stimulate tumorigenesis in various cancers via regulating cell signalling, ...

On a sugar high: Role of O-GlcNAcylation in cancer

This protein modification is catalyzed by an enzyme called O-GlcNAc transferase (OGT), which uses the final product of the Hexosamine ...

Elevated O-GlcNAcylation promotes colonic inflammation and ...

Because the cellular roles of O-GlcNAc-modified proteins are perturbed during tumorigenesis, aberrant O-GlcNAcylation was suggested to be ...

O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis

HCC cell lines were employed to examine the effects of RACK1 O-GlcNAcylation on the translation of oncogenic factors and behaviors of tumor cells in vitro.

The Role of Translation Control in Tumorigenesis and Its ...

It thereby serves as the Achilles' heel for cancer cells, particularly in response to changes in the microenvironment as well as to nutrient and ...

Nutrient sensor O-GlcNAc transferase regulates breast cancer ...

We discovered that breast cancer cells upregulate the HBP, including increased O-GlcNAcation and elevated expression of O-GlcNAc transferase ( ...

O-GlcNAcylation promotes tumor immune evasion by inhibiting PD ...

Reducing O-GlcNAc sensitizes cancer cells to immune cell killing, and inhibits tumor growth in mice. The study enhances our understanding of ...

O-GlcNAcylation in tumorigenesis and its implications for cancer ...

In this review, we discuss the tumor-related biological functions of O-GlcNAcylation and summarize the recent progress in the development of ...

Role of tumor microenvironment in tumorigenesis - Journal of Cancer

These CAFs have a significant impact on cancer progression through remodeling ECM, inducing angiogenesis, recruiting inflammatory cells, and directly ...

Hallmarks of Cancer: The Next Generation - Cell Press

The effects of surgery on tumor growth: a century of investigations. Ann ... MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities ...

The impact of the human microbiome in tumorigenesis, cancer ...

In summary, the human microbiome and its potential link to cancer has prompted great scientific interest in recent years. Although only one ...

Chromatin and Cancer: Implications of Disrupted Chromatin ... - MDPI

This disruption in heterochromatin can facilitate the initiation of tumorigenesis, the diversification of cells within the tumor, or a combination of both. This ...

Hallmarks of Cancer: New Dimensions - AACR Journals

By variously corrupting the normal differentiation of progenitor cells into mature cells in developmental lineages, tumorigenesis and malignant ...

Roles of trans-lesion synthesis (TLS) DNA polymerases in ...

... the underlying etiology of other human cancers is unclear. Here we consider the broad impact of TLS polymerases on tumorigenesis and cancer therapy. We ...

An Updated Review on Implications of Autophagy and Apoptosis in ...

Autophagy has been said to have a complicated role in tumorigenesis. In the early stages of tumor formation, autophagy appears to be salutary.