- O|GlcNAcylation promotes tumor immune evasion by inhibiting PD ...🔍
- O|GlcNAcylation in tumorigenesis and its implications for cancer ...🔍
- O|GlcNAcylation promotes tumor immune evasion by ...🔍
- O|GlcNAcylation at the center of antitumor immunity🔍
- The roles of OGT and its mechanisms in cancer🔍
- O|GlcNAcylation🔍
- PD|L2 glycosylation promotes immune evasion and predicts anti ...🔍
- O|GlcNAc signaling🔍
O|GlcNAcylation promotes tumor immune evasion by inhibiting PD ...
O-GlcNAcylation promotes tumor immune evasion by inhibiting PD ...
Our study reveals a link between O-GlcNAc and tumor immune evasion, and suggests strategies for improving PD-L1-mediated immune checkpoint blockade therapy.
O-GlcNAcylation promotes tumor immune evasion by inhibiting PD ...
O-GlcNAc suppresses the degradation of the programmed death ligand 1 (PD-L1) in cancer cells, the level of which is closely associated with cancer immune ...
O-GlcNAcylation in tumorigenesis and its implications for cancer ...
O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation. Proc. Natl. Acad. Sci. U. S. A. 2023;120 doi ...
O-GlcNAcylation promotes tumor immune evasion by ... - BVS
... O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation. ... Tumor Escape / B7-H1 Antigen Limits: Animals Language: En ...
O-GlcNAcylation at the center of antitumor immunity - ScienceDirect
Yi, et al. O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation. Proc Natl Acad Sci, 120 (2023), Article e2216796120. View ...
O-GlcNAcylation promotes tumor immune evasion by inhibiting PD ...
O-GlcNAc inhibition activates T cell-mediated antitumor immunity in vitro and in immune-competent mice in a manner dependent on HGS glycosylation. Combination ...
The roles of OGT and its mechanisms in cancer - Cell & Bioscience
... tumor immune escape, and ultimately enhances tumor ... O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation.
O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and ...
... cancer, by promoting tumor growth and immune escape. Among the ... O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation.
PD-L2 glycosylation promotes immune evasion and predicts anti ...
Increased expression and glycosylation of immune checkpoint molecules in tumors are responsible for cetuximab therapy refractoriness. The role of programmed ...
O-GlcNAc signaling: implications for stress-induced adaptive ...
... O-GlcNAc glycosylation. Sci Signal. (2013). Q. Zhu et al. O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal ...
N-linked glycosylation of PD-L1/PD-1: an emerging target for cancer ...
O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation. Proc Natl Acad Sci USA. 2023;120(13):e2216796120 ...
Promoting anti-tumor immunity by targeting TMUB1 to modulate PD ...
Collectively, these results suggested that TMUB1 could increase the PD-L1 levels in cancer cells and promote immune evasion. TMUB1 stabilizes PD ...
EPDR1 promotes PD-L1 expression and tumor immune evasion by ...
Immune checkpoint blockade (ICB) has the potential to disrupt the immune escape of cancer cells by removing inhibitory signals of T-cell ...
The hallmarks of cancer immune evasion - Cell Press
133. Liu, H. ∙ Kuang, X. ∙ Zhang, Y. ... ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell.
A20 promotes colorectal cancer immune evasion by upregulating ...
We found that A20 downregulation prominently improved the antitumor immune response and the efficacy of PD-1 inhibitor in CRC in vitro and in vivo.
Protein O-fucosyltransferase 1 promotes PD-L1 stability to drive ...
We identified POFUT1 as a crucial promoter of immune evasion in liver cancer. Notably, POFUT1 promoted HCC progression and inhibited T-cell infiltration.
GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 ...
O -GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation. Proc. Natl. Acad. Sci. U.S.A.. Pub Date : 2023-03-21
The Extrinsic and Intrinsic Roles of PD-L1 and Its Receptor PD-1
On tumors, PD-L1 binding to PD-1 on immune cells promotes immune evasion and tumor progression, primarily by inhibition of cytotoxic T lymphocyte effector ...
PD-L1 on tumor cells is sufficient for immune evasion in ...
MC38-derived PD-L1 potently inhibited CD8+ T cell cytotoxicity. Wild-type MC38 cells outcompeted PD-L1–deleted MC38 cells in vivo, demonstrating tumor PD-L1 ...
DKK1 Promotes Tumor Immune Evasion and Impedes Anti–PD-1 ...
Results from in vitro coculture assays suggested that DKK1 induces macrophages to become immunosuppressive, thereby inhibiting antitumor responses of CD8+ T ...