ONSL and OSKM cocktails act synergistically in reprogramming ...

ONSL gene reprograms more efficiently than OSKM but OSKM reprograms faster suggesting that the two cocktails may reprogram through distinct pathways.

When mixed, ONSL and OSKM polycistronic genes synergized the reprogramming process, allowing it to reach an efficiency of over 2% of the treated cells.

ONSL and OSKM cocktails act synergistically in reprogramming ...

The advent of human induced pluripotent stem cells (hiPSC) is revolutionizing many research fields including cell-replacement therapy, drug screening, ...

ONSL and OSKM cocktails act synergistically in reprogramming ...

ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells. by Laura Jung, Philippe Tropel, ...

ONSL and OSKM cocktails act synergistically in reprogramming ...

ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells ... Authors: L. Jung; P. Tropel; Y. Moal; M.

ONSL and OSKM cocktails act synergistically in reprogramming ...

ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells. by Laura Jung, ...

The occurrence and development of induced pluripotent stem cells

As the understanding of and research on reprogramming increases, OSKM ... ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into ...

Comparison of ONSL and OSKM polycistronic efficiency when ...

The use of cocktails consisting of OSKM and ONSL (i.e., OCT4, NANOG, SOX2, and Lin28) and the combination of OCT4, SOX2, and NANOG have been shown to be ...

Epigenetics of Reprogramming to Induced Pluripotency

Notably, by supplementing OSKM-reprogramming cultures with a growth factor cocktail ... The idea of OSK acting as pioneer factors in reprogramming ...

NKX3-1 is required for induced pluripotent stem cell reprogramming ...

Reprogramming efficiencies of the NSK cocktail are very similar to the OSK cocktail ... ONSL and OSKM cocktails act synergistically in reprogramming human ...

Cécile André's research works | Institut de Génétique et de Biologie ...

Interestingly, in this context ONSL gene reprograms more efficiently than OSKM but OSKM reprograms faster suggesting that the two cocktails may reprogram ...

New reprogramming factor cocktail produces therapy-grade induced ...

By comparison, only 20-30% of high quality OSKM passed the same test. Buganim hypothesizes that SNEL reprograms cells better because, unlike ...

Multi-omics characterization of partial chemical reprogramming ...

Association of gene expression log-fold changes in aged fibroblasts and induced by chemical reprogramming cocktails with established transcriptomic signatures ...

Reprogramming the Cardiac Field - Academia.edu

Related papers. ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells · Régis Gayon. Molecular ...

Effects of mechanical stimulation on the reprogramming of somatic ...

ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells. Mol Hum Reprod. 2014 ...

Transcriptome Signature and Regulation in Human Somatic Cell ...

Mesenchymal-to-epithelial transition (MET) occurs in the initial phase of reprogramming and is synergistically activated by OCT4, SOX2, KLF4, and MYC (OSKM) and ...

The transcription factor code in iPSC reprogramming - ScienceDirect

These findings indicate that cell fate specification is highly plastic during OSKM-induced somatic cell reprogramming, and that one ...

Effects of mechanical stimulation on the reprogramming of somatic ...

Jung L, Tropel P, Moal Y, Teletin M, Jeandidier E, Gayon R, et al. ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced ...

NANOG and LIN28 dramatically improve human cell reprogramming ...

Two gene cocktails, OCT4, SOX2, KLF4, and MYC (OSKM) ... (B) Number of TRA-1-60+ colonies in OSKM- and +GNL-mediated reprogramming conditions on days 10 and 21.

Publications du MMG: MMG - Marseille Medical Genetics

ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells. The advent of human induced pluripotent ...