Oligogenic inheritance

Oligogenic inheritance represents an intermediate between monogenic inheritance in which a trait is determined by a single causative gene, and polygenic ...

Genetic Modifiers and Oligogenic Inheritance - PMC - NCBI

In this review, we analyze the genetic properties and behaviors of modifiers as derived from studies in patient populations and model organisms.

Oligogenic - Genomics Education Programme

Environmental factors may also be implicated. Oligogenic inheritance has been associated with several conditions, including breast cancer, ...

Oligogenic inheritance in severe adult obesity - Nature

The genetic architecture of extreme non-syndromic obesity in adults remains to be elucidated. A range of genes are known to cause monogenic ...

Editorial: Monogenic vs. Oligogenic Reclassification - Frontiers

By conducting an oligogenic inheritance approach in analyzing exome sequencing data, the authors identified five pathogenic variants in different skeletal ...

Digenic or oligogenic mutations in presumed monogenic disorders

Oligogenic inheritance refers to the presence of mutations in multiple genes, typically three or more, that collectively contribute to the ...

Unraveling the mystery of oligogenic inheritance under way? - NCBI

Unraveling the mystery of oligogenic inheritance under way? Yerim Lee and Jaesang Kim ⁎ Author information Article notes Copyright and License information

Oligogenic inheritance of a human heart disease involving a genetic ...

Here, we show that a human cardiac anomaly can be caused by a combination of rare, inherited heterozygous mutations. Whole-exome sequencing of a ...

Oligogenic Inheritance Underlying Incomplete Penetrance of ...

Oligogenic Inheritance Underlying Incomplete Penetrance of PROKR2 Mutations in Hypogonadotropic Hypogonadism ... The role of the prokineticin 2 ...

New findings in oligogenic inheritance of congenital ...

In this study we report on new genetic findings supporting the importance of oligogenic inheritance in congenital hypogonadotropic hypogonadism.

An oligogenic inheritance test detects risk genes and their ... - bioRxiv

We developed an efficient, simulation-based method to detect gene sets that carry damaging variants in probands at a higher rate than expected given parental ...

Oligogenic inheritance in neuroblastoma - ScienceDirect.com

On the basis of the current data, familial NB cannot be modeled as a Mendelian monogenic trait. Instead, an oligogenic mode of inheritance might explain the ...

Evidence for oligogenic inheritance of type 1 diabetes in a large ...

Based on a genomic search for linkage, a locus contributing to type 1 diabetes in a large Bedouin Arab family (19 affected relatives) maps to the long arm of ...

Oligogenic basis of isolated gonadotropin-releasing hormone ...

Elucidating the principles of oligogenic inheritance and the underlying genetic interactions should help to understand how rare variants contribute to the more ...

Oligogenic inheritance – Knowledge and References

The best known example of genetic pleiotropy within the group of ataxias is CACNA1A mutations that can present as SCA6, episodic ataxia type II and familial ...

Oligogenic mode of inheritance – Lancaster Glossary of Child ...

Oligogenic mode of inheritance ... Inheritance pattern requiring the influence of a few (two or three) genes. Previously, diseases regarded as ...

Oligogenic character | biology - Britannica

Many such inherited differences exist, and they frequently have profound effects on plant value and utilization. Examples are… Read More. type of character. In ...

Oligogenic Inheritance - Semantic Scholar

Oligogenic Inheritance. Known as: Oligogenic Traits, Inheritance, Oligogenic, Oligogenic Inheritances Expand. A phenotypic outcome (physical characteristic or ...

Oligogenic heterozygous inheritance of sperm abnormalities in mouse

This study provides insights into the detrimental effect of accumulative heterozygous mutations on sperm abnormalities.

Oligogenic inheritance of a human heart disease involving a genetic ...

Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, ...