Optimizing sgRNA position markedly improves the efficiency of ...

We analyzed 155 sgRNAs targeting 41 genes and found that CRISPRi efficiency relies heavily on the precise recruitment of the effector complex to the target ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Aliaksandra Radzisheuskaya1,2 ...

[PDF] Optimizing sgRNA position markedly improves the efficiency ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression · A. Radzisheuskaya, Daria Shlyueva, +1 author. K.

(PDF) Optimizing sgRNA position markedly improves the efficiency ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. June 2016; Nucleic Acids ...

Optimizing sgRNA position markedly improves the efficiency of ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression-article.

Optimizing sgRNA position markedly improves the efficiency of ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. by Aliaksandra Radzisheuskaya, ...

Optimizing sgRNA position markedly improves the efficiency of ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression-article.

Optimizing sgRNA to Improve CRISPR/Cas9 Knockout Efficiency

Further, TCRα constant (TRAC) or beta-2-microglobulin (B2M) gene knocked-out CD19-specific CAR T cells may markedly result in reduced GVHD ...

Optimizing sgRNA position markedly improves the efficiency of ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression-article.

(Open Access) Optimizing sgRNA position markedly improves the ...

TL;DR: This work provides a framework for efficient CRISPRi assay design based on functionally defined TSSs and features of the target site chromatin, with high ...

Optimizing sgRNA structure to improve CRISPR-Cas9 knockout ...

... position 4 to cytosine or guanine significantly increases gene knockout efficiency in CRISPR-Cas9-based genome editing experiments.

[PDF] Sequence determinants of improved CRISPR sgRNA design

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression · Biology. Nucleic acids research · 2016.

EpiCas-DL: Predicting sgRNA activity for CRISPR-mediated ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic Acids Res, 44 (2016), p. e141.

How to Design Your gRNA for CRISPR Genome Editing

... optimal location. It is also ... sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression.

Optimized libraries for CRISPR-Cas9 genetic screens with multiple ...

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic Acids Res. 44, e141 ...

CGD: Comprehensive guide designer for CRISPR-Cas systems

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucl Acids Res, 44 (18) (2016), p. e141.

CRISPR–Cas9 Structures and Mechanisms - Annual Reviews

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic Acids Res 44:18e141 ...

Refined sgRNA efficacy prediction improves large- and small-scale ...

... increase in performance was found for sgRNAs ... et al. Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA ...

Compact and highly active next-generation libraries for CRISPR ...

(2016) Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic Acids Research ...

Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity

... position on cleavage efficiency. Name ... 25. Dang, Y. ∙ Jia, G. ∙ Choi, J. ... Optimizing sgRNA structure to improve CRISPR-Cas9 knockout efficiency.