Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in ...

Excessive inhibition of the external globus pallidus (GPe) by striatal GABAergic neurons is considered a central mechanism contributing to ...

Optogenetic Globus Pallidus Stimulation Improves Motor ... - HAL

Sham/controls, Tukey's post-hoc test, Figure 1L). 144. 2.2. GPe photostimulation improves locomotor hypoactivity and bradykinesia in 6-OHDA-.

Excessive inhibition of the external globus pallidus (GPe) by striatal GABAergic neurons is considered a central mechanism contributing to motor symptoms of ...

Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in ...

Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in 6-Hydroxydopamine-Lesioned Mouse Model of Parkinson's Disease.

IJMS | Free Full-Text | Optogenetic Globus Pallidus Stimulation ...

Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in 6-Hydroxydopamine-Lesioned Mouse Model of Parkinson's Disease. Int. J. Mol. Sci. 2023, 24 ...

Optogenetic Stimulation of GABAergic Neurons in the Globus ...

The globus pallidus (GP) is emerging as a critical locus of basal ganglia control of motor activity, but the exact role of GABAergic GP neurons ...

Frequency-Specific Optogenetic Deep Brain Stimulation of ...

High-rate optogenetic DBS generated both increases and decreases in firing rates of single neurons in STN, globus pallidus externa (GPe), and ...

Chemogenetic and optogenetic stimulation of zona incerta ...

Bilateral ZI DBS alleviates motor symptoms, especially tremor, and improves activities of daily living and quality of life in PD patients.

The globus pallidus orchestrates abnormal network dynamics in a ...

Our mCx optogenetic inhibition was associated with a reduction in the firing rate of STN neurons and a consequent decrease in the coherence ...

Differential remodeling of subthalamic projections to basal ganglia ...

Optogenetic inhibition of either the STN-SNr or STN-GPi projection improves parkinsonian bradykinesia. These results suggest that the STN-GPi ...

Experimental investigation into the role of the subthalamic nucleus ...

Motor coordination required in advanced tasks is lost upon optogenetic STN excitation. Abstract. The subthalamic nucleus (STN) is critical for ...

Optogenetic Stimulation of the M2 Cortex Reverts Motor Dysfunction ...

Strikingly, optogenetic activation of M2 neurons or axons into the dorsomedial striatum increases striatal levels of dopamine and evokes ...

Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in ...

Di Bisceglie Caballero · S Ces · A Liberge · M Ambroggi · F Amalric · M Ouagazzal · A-M external globus pallidus motor behavior mice optogenetic Parkinson's disease ...

Deep brain stimulation in the globus pallidus alleviates motor activity ...

In conclusion, our results suggested that GP-DBS improved the motor symptoms of PD model rats, so the GP nucleus is expected to become a new ...

[PDF] Optogenetic Stimulation of GABAergic Neurons in the Globus ...

Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in 6-Hydroxydopamine-Lesioned Mouse Model of Parkinson's Disease · Sonia Di Bisceglie ...

Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus ...

Cell-type specific optogenetic STN DBS improved motor symptoms in PD rats. •. Optogenetic STN DBS modulated BOLD signals in SNr, GP, and CPu. •.

Role of the globus pallidus in motor and non-motor symptoms

The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary ...

Neuronal and synaptic adaptations underlying the benefits of deep ...

Unilateral or bilateral optogenetic stimulation of the Pf-STN terminal significantly improves locomotion and alleviates severe akinesia in a ...

Optogenetic investigation into the role of the subthalamic nucleus in ...

The results demonstrate that selective optogenetic inhibition of the subthalamic nucleus enhances locomotion while its excitation reduces ...

Neuron type-specific optogenetic stimulation for differential stroke ...

We found that selective stimulation of inhibitory neurons resulted in significantly greater motor recovery than stimulation of excitatory ...