Optogenetics to restore neural circuit function in Parkinson's disease

Optogenetics could be proposed as a means to restore neural circuit dysfunction-related diseases, such as affective disorders, dystonia, and PD.

Optogenetic approaches to evaluate striatal function in animal ...

Here, we focus on how optogenetics has been used over the last decade to probe striatal circuits that are involved in Parkinson disease.

Optogenetic Restoration of Basal Ganglia Function to Treat ...

Study Rationale: Optogenetics has gained wide interest as a tool to understand the function of circuits influencing brain diseases.

Optogenetic Globus Pallidus Stimulation Improves Motor Deficits in ...

In normal mice, GPe photoinhibition had little effect on motor behavior but promoted cognitive functions. These findings shed new light on GPe ...

The Roles of Optogenetics and Technology in Neurobiology: A Review

Such as exploring unknown neuron functions (Figure 1), the discovery of neural circuits (Figure 2), and treatment of neurological diseases (Figure 3). By using ...

Deep brain stimulation-guided optogenetic rescue of parkinsonian ...

Here, using in vivo electrophysiology, optogenetics, behavioral tasks and mathematical modeling, we found that subthalamic stimulation ...

Optogenetic neuroregeneration - Neural Regeneration Research

Already shortly after its inception, optogenetics was harnessed to understand neural circuit function in animal models of neurological and neurodegenerative ...

Application of Optogenetics in Neurodegenerative Diseases

2020). With a deeper understanding of the genetic underpinnings of NDDs, there is a growing need for more precise tools to study neuronal ...

Optogenetic Stimulation of the M2 Cortex Reverts Motor Dysfunction ...

Neuromodulation of deep brain structures (deep brain stimulation) is the current surgical procedure for treatment of Parkinson's disease (PD).

Optogenetic and designer receptor insights for Parkinson's disease

Optogenetics and novel designer receptors have revolutionized the way neuroscientists can interrogate neural circuits. These new tools are being rapidly ...

Optogenetic investigation of neural circuits in vivo - Stanford Medicine

Parkinson's disease. Parkinson's disease is a neurodegenerative disorder ... and their role in mediating cortical circuit performance, remain unknown.

Optogenetics and its application in neural degeneration and ...

... Optogenetic neuronal stimulation promotes functional recovery after stroke. ... (2009) Optical deconstruction of Parkinsonian neural circuitry. Sci- ence ...

Targeting Neural Circuits: Cell

Optogenetic methodology enables direct targeting of specific neural circuit elements for inhibition or excitation while spanning timescales.

Application of Optogenetics in the Regulation of Neural Circuits in ...

The study also suggests that optogenetic stimulation of glutamatergic neurons in the mesocerebellar nucleus may improve motor function in PD mouse models, ...

Optogenetics in Brain Research: From a Strategy to Investigate ...

Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in basic neuroscience and in all the biomedical field.

Optogenetic Approaches to Target Specific Neural Circuits in Post ...

Optogenetic manipulation of neuronal subtypes and neural circuits has proven to be particularly useful in investigating various neurological ...

Optogenetics 2.0: challenges and solutions towards a quantitative ...

Optogenetics pioneered the causal interrogation of not only local but also brain wide functional connectivity. Particularly, it opened up the ...

Optogenetic delivery of trophic signals in a genetic model of ... - PLOS

This has been to date achieved by the regulation of ion flow and electrical signals in neuronal cells and neural circuits that are known to be affected by ...

Frequency-Specific Optogenetic Deep Brain Stimulation of ...

High-rate optogenetic STN DBS can indeed ameliorate parkinsonian motor symptoms through reduction of abnormal oscillatory activity in the STN-associated neural ...

A new brain mapping technique reveals circuitry of Parkinson's ...

Increased blood flow is associated with increased activity. Using optogenetics to turn on a specific type of neuron, and fMRI to observe how ...