Organ Farming and Interspecies Chimeras

Organ Farming and Interspecies Chimeras - NYU Langone Health

Organ Farming and Interspecies Chimeras. Overview. This module examines the ethical issues surrounding human-animal chimeras and their use in the production ...

Interspecies chimeras as a platform for exogenic organ production ...

The overall goal for interspecies chimeric organ production is to engineer an unlimited source of organs for clinical transplantation as ...

Human–animal chimeras: ethical issues about farming chimeric ...

... interspecies chimeras, such as animals bearing an organ from another species ... farming chimeric animals bearing human organs. Rodolphe ...

Generating Human Organs via Interspecies Chimera Formation

An alternative and promising strategy is to generate human organs inside large animal species through a technique called interspecies blastocyst ...

Towards human organ generation using interspecies blastocyst ...

Chimera formation rate refers to the percentage of host animals with donor cells. Assessment of chimera formation requires checking the markers ...

Interspecies Chimeras and the Generation of Humanized Organs

Alternative strategies are being developed including the use of interspecies chimeras to generate humanized hearts in gene-edited pigs. These ...

Interspecies chimeras - ScienceDirect.com

Thus, a human organ grown in a livestock animal could provide patient-matched organs and eliminate the organ transplant waiting list. This article will review ...

Interspecies Chimeric Barriers for Generating Exogenic Organs and ...

By overcoming the interspecies chimera barriers and creating highly competent chimeras, the technology of organ and cellular generation can be ...

Human-animal chimeras for autologous organ transplantation

Human-animal chimeras provide the ability to produce human organs in other species using autologous stem cells [e.g., induced pluripotent stem cells (iPSCs) or ...

Moral uncertainty and the farming of human-pig chimeras

It may soon be possible to generate human organs inside of human-pig chimeras via a process called interspecies blastocyst complementation. This paper discusses ...

Growth Competition in Interspecies Chimeras: A New Paradigm for ...

As the chimeric embryo develops, the emptied organ niche can be exclusively filled by xenogeneic donor cells. Since the first generation of a ...

Xenotransplantation and interspecies organogenesis: current status ...

On the other hand, interspecies chimera-derived human organ transplantation aims to generate organs derived from the patient's own iPSCs, which ...

Interspecies Chimeras and the Generation of Humanized Organs

These interspecies chimeras will pro- vide a unique research model and impact the treatment of chronic, end-stage disease such as heart failure.

Partial Humanity - Harvard Medical School Center for Bioethics

Research into chimeric transplantation has the potential to solve the problem of organ scarcity, conferring vast societal benefits. However, ...

New concepts for generating interspecies chimeras using human ...

As the chimeric embryo develops, donor cells can fill the vacated developmental organ niche and enrich in a target organ of interest. In ...

Generation of human-pig chimeric renal organoids using iPSC ...

transplantation have garnered attention, but both face technical challenges. Interspecies chimeric organ production using human iPSCs shows ...

Interspecies Chimerism with Mammalian Pluripotent Stem Cells

We find that naïve hPSCs robustly engraft in both pig and cattle pre-implantation blastocysts but show limited contribution to post-implantation ...

The road to generating transplantable organs: from blastocyst ...

Chimeras generated between different species (interspecies chimeras), on the other hand, have helped researchers understand evolutionarily ...

Stanford Medicine researchers take early, critical step toward ...

A new technique, developed at Stanford, for generating chimpanzee stem cells may lay the groundwork for eventually developing human organs in animals.

Human-Animal Chimeras Are Gestating on U.S. Research Farms

A radical new approach to generating human organs is to grow them inside pigs or sheep. By. Antonio Regaladoarchive page. January 6, 2016.