Organic Cation Transporter 2 Mediates Cisplatin|Induced Oto

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto

OCT2 has been proposed as target for protective therapeutic interventions accompanying cisplatin treatment. In vitro studies showed that administration of ...

Organic cation transporter 2 mediates cisplatin-induced oto - PubMed

The use of the effective antineoplastic agent cisplatin is limited by its serious side effects, such as oto- and nephrotoxicity.

Interaction of Cisplatin with the Human Organic Cation Transporter 2

OCT2-mediated transport of cisplatin was saturable, and uptake was increased by ∼4-fold (P < 0.0001) relative to control cells. Cisplatin ...

Commentary Organic cation transporter OCT/SLC22A and H + ...

Ciarimboli et al. Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol.

Membrane Transporters as Mediators of Cisplatin Side-effects

E: Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol 176: 1169-1180 ...

Cimetidine as an Organic Cation Transporter Antagonist

This Correspondence relates to “Organic transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions”

The Mechanotransduction Channel and Organic Cation Transporter ...

In cancer cells, copper transport 1 (CTR1) and organic cation transporter 2 (OCT2) have been revealed to mediate cisplatin uptake (Harrach and Ciarimboli, 2015) ...

Membrane Transporters as Mediators of Cisplatin Side-effects

: Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol 176: 1169-1180 ...

Current Understanding of Membrane Transporters as Regulators or ...

(2010) Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol ...

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto

The use of the effective antineoplastic agent cisplatin is limited by its serious side effects, such as oto- and nephrotoxicity. Ototoxicity is a problem of ...

Organic Cation Transporter 2 - an overview | ScienceDirect Topics

OCT2 mediates the release of organic cations across the basolateral membrane if the outwardly directed substrate gradient is sufficiently high.

Exacerbation of Cisplatin Cellular Toxicity by Regulation of ... - MDPI

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions. Am. J. Pathol. 2010, 176, 1169 ...

Influence of Oct1/Oct2-Deficiency on Cisplatin-Induced Changes in ...

, et al. Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions . Am J Pathol. 2010.

OCT2 - Transporters - Solvo Biotechnology

Ciarimboli, G., et al., Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am ...

Cimetidine as an Organic Cation Transporter Antagonist

AH, Koepsell H, Jürgens H, Schlatter E: Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective ...

Acta Physiologica Congress

ORGANIC CATION TRANSPORTER 2 MEDIATES CISPLATIN-INDUCED OTO- AND NEPHROTOXICITY AND IS TARGET FOR PROTECTIVE INTERVENTIONS Abstract number: O-MON-7-6.

Role of transporters in the distribution of platinum-based drugs

Organic cation transporter 2 mediates cisplatin-induced oto ... Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.

Organic Cation Transporter 2 Overexpression May Confer an ...

Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol 176:1169–1180. Go ...

Role of membrane transportors in cisplatin induced nephrotoxicity

(2010) Organic cation transporter 2 mediates cisplatin-induced oto-and nephrotoxicity and is a target for protective interventions. Am J ...

Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity

Request PDF | Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity | Cisplatin is an effective but highly nephrotoxic antineoplastic agent ...