Overcoming Drug Resistance in Pancreatic Cancer

Overcoming Drug Resistance in Pancreatic Cancer - PubMed Central

Drug resistance is a key factor that limits the choice of therapies and significantly decreases the efficacy of any chemotherapy drugs for pancreatic cancer.

Overcoming therapy resistance in pancreatic cancer: New insights ...

There are three treatment options in clinical use: (i) Gemcitabine monotherapy; (ii) combination Gemcitabine and Capecitabine (an oral precursor of 5- ...

Overcoming drug resistance in pancreatic cancer - PubMed

Increasing drug delivery efficiency and decreasing drug resistance is the current aim in pancreatic cancer treatment, and will also benefit the treatment of ...

Uncovering the Mechanism for Drug Resistance in Pancreatic Cancer

Researchers at the University of Virginia have discovered a new mechanism driving drug resistance in pancreatic ductal adenocarcinoma, one of ...

Reversing chemotherapy resistance in pancreatic cancer

They found that pancreatic cancer needed two things to become resistant to chemotherapy: a physically stiff extracellular matrix and high ...

A New Approach to Overcome Drug Resistance

In their quest to impact the difficult-to-target KRAS protein (found in more than 90 percent of pancreatic cancers), researchers set their ...

Conquering chemoresistance in pancreatic cancer: Exploring novel ...

Combination therapy, supported by nanomedicine, utilizes the synergistic effects of different drugs to target various resistance mechanisms, ...

Overcoming chemotherapy resistance in pancreatic cancer

Researchers have discovered that pancreatic cancer's resistance to chemotherapy is related to the physical stiffness of the extracellular matrix.

Overcoming Cancer Resistance: Strategies and Modalities for ...

A major problem in combatting cancer is drug resistance, which remains a formidable challenge in oncology, limiting the effectiveness of conventional and ...

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using ...

The priming of cancer cells to apoptosis with chemotherapeutic drugs has been shown to significantly increase the effectiveness of BCL-2 family inhibitors. In ...

The challenge of drug resistance in pancreatic ductal adenocarcinoma

Cancer cells expressing these transporters are generally referred to as multidrug resistant (MDR) cells. In this vein, overexpression of the ...

Overcoming drug resistance in pancreatic cancer

The current standard care for metastatic pancreatic cancer is gemcitabine, however, the success of this treatment is poor and overall survival has not improved ...

Role of c-MET Inhibitors in Overcoming Drug Resistance in ... - MDPI

Pancreatic stellate cells (PSCs) are a key component of tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and contribute to drug resistance.

New treatment strategy could overcome drug resistance in ...

“This work identifies one approach to overcome adaptive resistance to drugs for pancreatic cancer and demonstrates that the drug combination ...

Full article: Treatment resistance in pancreatic and biliary tract cancer

We provide a current overview and discussion of the most relevant mechanisms of resistance to chemotherapy, target therapy, and immunotherapy in both BTC and ...

Drug resistance in pancreatic cancer: New player caught in act

∙ Van Laethem, J.L. ∙ et al. Systemic treatment of pancreatic cancer revisited. Semin Oncol. 2018; [pii:S0093-7754(18)30266-5]. PubMed · Google Scholar. [3] ...

SOX2 and OCT4 mediate radiation and drug resistance in ... - Nature

Pancreatic cancer has a five-year survival rate of only 10%, mostly due to late diagnosis and limited treatment options.

Overcoming Drug Resistance in Pancreatic Cancer - ResearchGate

The current standard care for metastatic pancreatic cancer is gemcitabine, however, the success of this treatment is poor and overall survival has not improved ...

Overcoming drug resistance in pancreatic cancer - UC Library Search

Expert opinion on therapeutic targets Expert opinion on therapeutic targets. , 2011, Vol.15(7), p.1-828 ,. Overcoming drug resistance in pancreatic cancer ...

New study identifies a strategy to overcome drug resistance in ...

This work identifies one approach to overcome this hurdle for pancreatic cancer and demonstrates that the drug combination used can prevent drug ...