Overcoming Resistance to Temozolomide in Glioblastoma

Overcoming Resistance to Temozolomide in Glioblastoma - MDPI

Glioblastoma (GB) is the most common and most aggressive primary brain tumor in adults, with an overall survival almost 14.6 months.

Overcoming Resistance to Temozolomide in Glioblastoma - PubMed

Glioblastoma (GB) is the most common and most aggressive primary brain tumor in adults, with an overall survival almost 14.6 months.

Potential Strategies Overcoming the Temozolomide Resistance for ...

The increase in TMZ resistance is one of the main reasons for GBM treatment failure. O6-methylguanine-DNA methyltransferase (MGMT) is the most ...

An overview of glioblastoma multiforme and temozolomide resistance

TMZ chemotherapy administered with radiotherapy offers significantly superior prognosis for GBM patients, and hence it is widely considered as a first-line ...

Temozolomide resistance in glioblastoma multiforme - ScienceDirect

Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocytomas. However, at least 50% of TMZ treated patients ...

Overcoming Temozolomide Resistance in Glioblastoma via ... - MDPI

Glioblastoma multiforme (GBM) is an incurable brain cancer with an average survival of approximately 15 months. Temozolomide (TMZ) is a DNA alkylating agent ...

Therapeutic approaches to overcome temozolomide resistance in ...

Prior to 1996, the only form of treating GBM was resection followed by radiotherapy (RT), which extended survival from 3 to 9 months (Fig. 1) [1]. In 1996, ...

Nanomedicine-based combination therapies for overcoming ...

As a revolutionary gene editing tool, the CRISPR/Cas9 system has also been used to overcome challenges in GBM drug resistance. For example, Yang ...

Potential Strategies Overcoming the Temozolomide Resistance for ...

Glioblastoma (GBM) is a highly malignant type of primary brain tumor with a high mortality rate. Although the current standard therapy consists of surgery ...

Dissecting the mechanism of temozolomide resistance and its ...

As being the standard systemic treatment agent, TMZ is a second-generation imidazotetrazine lipophilic prodrug. Currently, it is perhaps the ...

Mitigating temozolomide resistance in glioblastoma via DNA ...

Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA-N-glycosylase (APNG) and methylguanine-DNA- ...

Overcoming Temozolomide Resistance in Glioblastoma via Dual ...

Temozolomide resistance in glioblastoma can be overcome by dual inhibition of NAD+ biosynthesis and base excision repair.

Characterization of EGFR-reprogrammable temozolomide-resistant ...

The acquisition of TMZ resistance is a major clinical challenge for GBM treatment, and related therapeutic strategies to overcome such ...

In search of effective therapies to overcome resistance to ...

Glioblastoma multiforme is the most common and lethal brain tumour-type. The current standard of care includes Temozolomide (TMZ) chemotherapy.

Potential Strategies Overcoming the Temozolomide Resistance for ...

246 Citations · Nitric Oxide Prevents Glioblastoma Stem Cells' Expansion and Induces Temozolomide Sensitization · Establishment of a Novel Temozolomide Resistant ...

A Potential Mechanism of Temozolomide Resistance in Glioma ...

Furthermore, a number of studies have found that TMZ treatment could induce autophagy to help glioma cells resist the TMZ treatment (16, 29).

Full article: Therapeutic Perspective of Temozolomide Resistance in ...

Glioblastoma (GB) is the most aggressive grade IV brain tumor with a poor prognosis, high recurrence rate, and low survival rate. GB accounts for more than half ...

Overcoming therapeutic resistance in glioblastoma: the way forward

Standard therapy for GBM encompasses maximally safe surgical resection followed by radiation and chemotherapy (1–4). While many patients' tumors ...

The combination of temozolomide and perifosine synergistically ...

Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is ...

Targeting autophagy to sensitive glioma to temozolomide treatment

TMZ is considered the most effective drug in the treatment for GBM. However, its efficacy is often limited by tumor recurrence and the ...