Overcoming Temozolomide Resistance in Glioblastoma via ...

Glioblastoma multiforme (GBM) is an incurable brain cancer with an average survival of approximately 15 months. Temozolomide (TMZ) is a DNA ...

Overcoming temozolomide resistance in glioblastoma via dual ...

Glioblastoma multiforme (GBM) is a devastating brain tumor with poor prognosis and low median survival time. Standard treatment includes ...

Overcoming Temozolomide Resistance in Glioblastoma via ... - MDPI

Glioblastoma multiforme (GBM) is an incurable brain cancer with an average survival of approximately 15 months. Temozolomide (TMZ) is a DNA alkylating agent ...

Overcoming temozolomide resistance in glioblastoma through ...

Tumor resistance to TMZ often comes from overactivation of phosphoinositide 3-kinase (PI3K), making this enzyme an ideal anti-cancer drug target ...

Overcoming Temozolomide Resistance in Glioblastoma via Dual ...

Temozolomide resistance in glioblastoma can be overcome by dual inhibition of NAD+ biosynthesis and base excision repair.

Overcoming Resistance to Temozolomide in Glioblastoma - MDPI

Optimal resection followed by combined temozolomide chemotherapy and radiotherapy, also known as Stupp protocol, remains the standard of treatment; nevertheless ...

An overview of glioblastoma multiforme and temozolomide resistance

Methylation of the N7 site on guanine accounts for 70% of TMZ modification in cells, but no corresponding cytotoxicity has been found. In 9% of TMZ treatment ...

Mitigating temozolomide resistance in glioblastoma via DNA ...

Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA-N-glycosylase (APNG) and methylguanine-DNA- ...

Temozolomide resistance in glioblastoma multiforme - ScienceDirect

TMZ resistance is a major problem in the treatment of malignant brain tumors. Studies of numerous intrinsic and acquired TMZ resistant GBM cells indicate that ...

Nanomedicine-based combination therapies for overcoming ...

The standard GBM treatment involves maximal surgical resection, followed by postoperative radiotherapy and adjuvant chemotherapy with ...

Potential Strategies Overcoming the Temozolomide Resistance for ...

Glioblastoma (GBM) is a highly malignant type of primary brain tumor with a high mortality rate. Although the current standard therapy consists of surgery ...

Stanniocalcin-1 promotes temozolomide resistance of glioblastoma ...

Temozolomide (TMZ) resistance is a major challenge in the treatment of glioblastoma (GBM) ... temozolomide resistance of glioblastoma through ...

Dissecting the mechanism of temozolomide resistance and its ...

Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result ...

Elucidating the mechanisms of Temozolomide resistance in gliomas ...

The main concern in GBM treatment is the development of TMZ resistance. TMZ and other conventional chemotherapeutic drugs exert their anti-tumor action in ...

Characterization of EGFR-reprogrammable temozolomide-resistant ...

Temozolomide (TMZ) resistance is a major clinical challenge for glioblastoma (GBM). O6-methylguanine-DNA methyltransferase (MGMT) mediated ...

IRP1 mediated ferroptosis reverses temozolomide resistance in ...

The prognosis of glioblastoma (GBM) patients is poor, and temozolomide (TMZ) resistance has become an important obstacle to its treatment ...

Potential Strategies Overcoming the Temozolomide Resistance for ...

Recent reports demonstrated that new agents may be effective as single treatments or to synergistically enhance TMZ cytotoxicity against GSCs and eliminate GBM ...

Metformin treatment reduces temozolomide resistance of ...

Our results demonstrate that metformin might function through multiple pathways in partial restoration of TMZ sensitivity in glioblastoma cells, ...

A Potential Mechanism of Temozolomide Resistance in Glioma ...

Furthermore, a number of studies have found that TMZ treatment could induce autophagy to help glioma cells resist the TMZ treatment (16, 29).

Potential Strategies Overcoming the Temozolomide Resistance for ...

246 Citations · Nitric Oxide Prevents Glioblastoma Stem Cells' Expansion and Induces Temozolomide Sensitization · Establishment of a Novel Temozolomide Resistant ...