PDGF/PDGFR Signaling in Cardiovascular Disease

cardiovascular diseases. Keywords: PDGF/PDGFR signaling; Cardiovascular disease; Atherosclerosis; Cardiac fibrosis. Jing Wang, Dongcheng Cai ...

PDGF and cardiovascular disease - PubMed

Platelet-derived growth factor (PDGF) was identified in a search for serum ... Signal Transduction; Stress, Mechanical. Substances. Platelet-Derived ...

PDGF and cardiovascular disease - ScienceDirect.com

PDGF and cardiovascular disease—a clear association · In vivo modulators of PDGF gene and receptor expression · Animal models establish a role for PDGF signaling ...

PDGF/PDGFR Signaling in Cardiovascular Disease

The contemporary biomedical knowledge on the role of PDGF/PDGFR signaling and related mechanisms in promoting cardiovascular diseases is reviewed.

Platelet-derived growth factor receptor-α is essential for cardiac ...

In the developing heart, PDGFRα signaling directs migration and differentiation of epicardial-derived fibroblasts (86, 90). In the adult heart, PDGF signaling ...

PDGF-C and PDGF-D signaling in vascular diseases and animal ...

PDGF receptor activation has been particularly linked to angiogenesis where PDGFR-β expression especially correlates with increased vascularity and maturation ...

PDGFRβ signalling regulates local inflammation and synergizes ...

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (VSMCs). However, the direct effects ...

Platelet-Derived Growth Factor D Induces Cardiac Fibrosis and ...

These results show that PDGF-D, via PDGFR-β signaling, is a potent modulator of both vascular and connective tissue growth and may provide both ...

Full article: The prediction value of platelet-derived growth factor for ...

Second, PDGFR-β activation in mural cells may promote vascular maturation. Third, enhanced PDGFR-α signalling may improve the repair function of ...

PDGFR-b Signaling Regulates Cardiomyocyte Proliferation and ...

Hence,. PDGFR-b signaling might serve as a target for inducing heart regeneration, but PDGF-BB, as other studies have exhibited, is not an ...

Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial ...

PDGFs are key signaling molecules and important drug targets in the treatment of cardiovascular disease as multiple researchers have shown that delivery of ...

Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA ...

Therefore, PDGF/PDGR receptor signaling pathways play vital roles in regulating the homeostasis of blood vessels and the onset and development of CVDs, such as ...

Cardiomyocyte PDGFR-β signaling is an essential component of the ...

Cardiac-specific PDGFR-β–knockout mice develop ventricular dilatation and heart failure in response to pressure overload. (A) PCR of genomic DNA ...

PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and ...

The role of PDGFR signaling in heart regeneration is still unknown. We find that PDGFR-β signaling decreases in myocardium with age and that ...

The Role of Platelet-Derived Growth Factor Signaling in Healing ...

Platelet-derived growth factor isoforms exert potent fibrogenic effects through interactions with PDGF receptor (PDGFR)-α and PDGFR-β. In addition, PDGFR-β ...

Platelet-derived growth factor (PDGF) signaling directs ... - eLife

Mutation of pdgfra disrupts heart tube assembly in both zebrafish and mouse. Timelapse analysis of individual cardiomyocyte trajectories reveals ...

Platelet-Derived Growth Factor Signaling in the Lung ... - ATS Journals

Pdgf-d transcription in vascular smooth muscle cells is regulated via binding of Ets-1 and/or SP1 to the GGAT binding sites within the pdgf-d ...

The Role of Platelet-Derived Growth Factor Signaling in Healing ...

We hypothesized that PDGFR activation may regulate fibrosis and vascular maturation in healing myocardial infarcts. METHODS. Mice undergoing reperfused ...

derived growth factor signalling in cardiovascular disease

(i) How does platelet-derived PDGF act in a paracrine manner to impact the expression of PDGFR in endothelial cells,. VSMCs and infiltrated macrophages of ...

PDGF-B/PDGFR-β Signaling: A New Potential Therapeutic Target of ...

The study of Liao et al. [19 ]indicated that cardiac mast cells caused atrial fibrosis and thus stimulated AF through the PDGF-A signaling in ...