POLYMORPHISM OF DIHYDROPYRIMIDINE DEHYDROGENASE ...

Dihydropyrimidine dehydrogenase (DPD) polymorphisms knocking ...

This article discusses how personalisation of fluoropyrimidine treatment based on the identification of DPYD variants can mitigate toxicities and be cost ...

The clinical relevance of multiple DPYD polymorphisms on patients ...

Deleterious polymorphisms in the gene encoding DPD (DPYD) may result in severe reduction of DPD enzymatic activity that causes life-threatening toxicities ...

DPYD genetic polymorphisms in non-European patients with severe ...

Pre-treatment DPYD screening is mandated in the UK and EU to reduce the risk of severe and potentially fatal fluoropyrimidine-related ...

Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil ...

The rare DPYD variants, although at very low frequencies, may serve as important pharmacogenomic markers associated with the severe 5-FU toxicity in Japanese ...

POLYMORPHISM OF DIHYDROPYRIMIDINE DEHYDROGENASE ...

Dihydropyrimidine dehydrogenase (DPD) is the enzyme catalyzing the first step of pyrimidine metabolism. To date, genetic polymorphisms of ...

Dihydropyrimidine dehydrogenase gene (DPYD) polymorphism ...

Abstract. 2576. Background: DPYD gene encodes DPD, the rate-limiting enzyme responsible for catabolism of 5-FU and is responsible for > 85% of 5 ...

Clinical Relevance of Novel Polymorphisms in the ... - MDPI

Polymorphism of the dihydropyrimidine dehydrogenase (DPYD) gene may reduce DPD function, the main enzyme responsible for the metabolism of fluoropyrimidines.

Dihydropyrimidine Dehydrogenase Polymorphism c.2194G ... - MDPI

Dihydropyrimidine Dehydrogenase Polymorphism c.2194G>A Screening Is a Useful Tool for Decreasing Gastrointestinal and Hematological Adverse Drug Reaction Risk ...

and Capecitabine-related Toxicity Using Full Sequencing of DPYD

Background: Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of the degradation of pyrimidine base, and plays a pivotal ...

Relationship between Single Nucleotide Polymorphisms and ...

Especially the polymorphically expressed enzyme dihydropyrimidine dehydrogenase (DPD), encoded by DPD gene (DPYD), plays a crucial role in the pharmacology of ...

DPYD polymorphisms c.496A>G, c.2194G>A and c.85T>C and risk ...

Cancer patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at increased risk of severe fluoropyrimidine (FP)-related adverse events (AE).

Three different polymorphisms of the DPYD gene associated with ...

Dihydropyrimidine dehydrogenase deficiency secondary to polymorphisms in the DPYD gene can lead to significant toxicity associated with the ...

Role of dihydropyrimidine dehydrogenase deficiency in systemic ...

DPD deficiency is most often the result of genetic polymorphism in the DPYD gene that encodes DPD. DPYD is highly polymorphic, with more ...

Risk of treatment-related death in carriers of pathogenic DPYD ...

Background: Polymorphisms of the DPYD gene are present in 3-5% of the population and are associated with increased risk for grade ≥3 ...

Relationship Between Dihydropyrimidine Dehydrogenase Gene ...

compounds used in chemotherapy varied depending on DPYD gene polymorphisms. These mutations increased susceptibility to severe neutropenia - ...

Dihydropyrimidine Dehydrogenase Gene Variation and Its ...

Their result showed the prevalence of IVS14+1 G>A polymorphism in DPYD gene was 0.91% [30], less than the amount we found in our study. The other study was ...

Dihydropyrimidine dehydrogenase (DPYD) gene polymorphisms ...

Dihydropyrimidine dehydrogenase (DPYD) gene polymorphisms profiling in colon cancer patients treated with adjuvant chemotherapy in the randomized phase III ...

ready for routine clinical application within personalized medicine?

Several studies have demonstrated significant associations between severe toxicities by fluoropyrimidines and germline polymorphisms of DPD gene.

Dihydropyrimidine dehydrogenase (DPD) enzyme deficiency - eviQ

DPD deficiency occurs in patients who carry genetic variations in the dihydropyrimidine dehydrogenase (DPYD) gene. Fluoropyrimidine toxicity. About 10-40% of ...

Dihydropyrimidine Dehydrogenase Gene (DPYD) Polymorphism

Abstract. Background: Dihydropyrimidine dehydrogenase. (DPD) is the rate-limiting enzyme of the degradation of pyrimidine base, and plays a pivotal role in ...