Paired tumor|germline testing can enhance patient care

Paired tumor|germline testing can enhance patient care—with ...

Paired Tumor-Germline Testing as a Driver in Better Cancer Care

One implication of the data is that paired testing provides important information about a patient's cancer and its treatment and can address ...

Paired tumor-germline testing can enhance patient care—with ...

The American Society of Clinical Oncology released guidelines on the use of germline genetic testing panels in concert with tumor testing for cancer patients.

The Future of Parallel Tumor and Germline Genetic Testing - NCBI

The increasing adoption of parallel testing has revealed a greater number of germline findings in patients who otherwise would not have met ...

The Cancer Letter on X: "Paired tumor-germline testing can enhance ...

Paired tumor-germline testing can enhance patient care—with guidance from genetics specialists. Guest editorial by Rebecca Sutphen ...

Why Paired Tumor/Germline Testing? - View Blog Post - Ambry

This treatment can offer hope, as it is a targeted treatment option for specific ovarian cancer patients. The germline testing can identify ...

Comprehensive Paired Tumor/Germline Testing for Lynch Syndrome

Molecular germline testing confirms a diagnosis of LS in 24% to 67% of patients with MMR-deficient (MMRd) CRC and in 16% to 80% of those with ...

Comprehensive Paired Tumor/Germline Testing for Lynch Syndrome

Paired testing identified a cause for MMRd tumors in 76% and 61% of patients without and with prior LS germline testing, respectively. Findings ...

Few People with Cancer Undergo Germline Testing - NCI

Like biomarker tests, germline testing can help doctors determine the best treatments for patients, but such testing may also help identify ...

Experts Introduce Biomarker Testing: Paired Somatic and Germline ...

Dr. Calzone provides an overview of the emerging use of paired somatic and germline testing to inform cancer treatment decisions. She will explain the science ...

Points to consider for reporting of germline variation in patients ...

The advantages of tumor-normal paired testing include improving the somatic detection rate and streamlining results interpretation for both the tumor and ...

Aligning Germline Cancer Predisposition With Tumor-Based Next ...

Traditionally, the purpose of germline genetic cancer risk assessment has been to identify individuals at an increased risk for an inherited cancer who could ...

Indications for germline testing in cancer patients

Knowing when a genomic variant identified on a genomic tumor test is in the germline can impact a cancer patient's treatment options and risk for future ...

germline vs somatic testing for cancer: hereditary cancer syndromes

Patients diagnosed with a suspected hereditary cancer should receive genetic testing to: • Confirm if they have a hereditary cancer syndrome. • Guide treatment ...

Germline Testing Outside the Guidelines: Can it Address Health ...

Broad-based germline genetic testing for patients with various cancers can identify mutations that may warrant a change of treatment.

Germline Findings Among Tumors From Cancer Types Lacking ...

In genes with guidelines for hereditary testing (like BRCA1&2, MSH2, APC, etc.) a germline increases the chances of finding more cases in the ...

Germline and somatic testing for homologous repair deficiency in ...

We argue for the widespread adoption germline testing for all patients at the time of prostate cancer (PCa) diagnosis. Patients with metastatic ...

Limited Independent Follow-Up with Germline Testing of Variants ...

Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing ...

Paired tumor sequencing and germline testing in breast cancer ...

Identification of germline variants can help guide therapeutic and preventive interventions. Drawing from our experience in this study, we ...

Diagnostic yield and clinical relevance of expanded genetic testing ...

Compared to targeted testing approaches, eGT can increase the yield of detection of hereditary cancer predisposition in patients with a range of ...

Use of Treatment-Focused Tumor Sequencing to Screen for ...

Next-generation sequencing assays are capable of identifying cancer patients eligible for targeted therapies and can also detect germline ...