Pancreatic β|cells in type 1 and type 2 diabetes mellitus

Pancreatic β-cells in type 1 and type 2 diabetes mellitus - Nature

Conclusions. β-cell failure is the central event in both T1DM and T2DM but the pathways that lead to this failure are different. β-cell ...

Pancreatic β-cells in type 1 and type 2 diabetes mellitus - PubMed

Loss of functional β-cell mass is the key mechanism leading to the two main forms of diabetes mellitus - type 1 diabetes mellitus (T1DM) and type 2 diabetes ...

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 ...

In the insulitis lesion in type 1 diabetes, invading immune cells produce cytokines, such as IL-1β, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ. IL-1β ...

Pancreatic β-Cell Identity in Diabetes - PMC

In contrast to the destruction of β-cells typically seen in type 1 diabetes, type 2 diabetes generally results from high insulin demand due to peripheral ...

Pancreatic Beta-cell Dysfunction in Type 2 Diabetes - Sage Journals

As β-cell failure is one of the major components of the pathogenesis of T2DM, islet inflammation can be considered a part of it. It has been ...

Beta cells in type 2 diabetes: Science explained - MedicalNewsToday

Beta cells are cells in the pancreas that produce and release insulin in response to blood glucose levels. In people with type 2 diabetes, ...

Type 1 diabetes mellitus as a disease of the β-cell (do not ... - Nature

Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells in pancreatic islets that is mediated by ...

Pancreatic β cells: Gatekeepers of type 2 diabetes

Type 2 diabetes (T2D) occurs when insulin-producing β cells of pancreatic islets are unable to produce and/or release sufficient insulin to ...

Partners in Crime: Beta-Cells and Autoimmune Responses ...

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated destruction of insulin-producing pancreatic beta-cells. Loss of ...

Clinical expert consensus on the assessment and protection of ...

Protecting islet β-cell function is vital to delay the progress of type 2 diabetes mellitus. Therefore, the Pancreatic Islet β-cell Expert Panel of the Chinese ...

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type ...

The islet in type 2 diabetes is characterized by deposits of amyloid (12) derived from the peptide islet amyloid polypeptide (IAPP), also known ...

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 ...

Obesity is one of the important factors for insulin resistance. Recently, in normal rodents β-cell mass and body mass were shown to be linearly correlated, ...

Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 ... - MDPI

2. Reduced Expression Levels of Insulin Gene Transcription Factors Such as PDX-1 and MafA Are Involved in Pancreatic β-Cell Failure Found in Type 2 Diabetes ...

Insulin-Producing Beta Cells Are Not Irreversibly Lost in Early Type ...

Type 2 diabetes is a progressive disease over time, and previous research has suggested beta cell death is the root cause of increasing failure ...

β-cell secretory dysfunction: a key cause of type 2 diabetes

However, in most people, insulin availability far exceeds functional requirements; in a healthy pancreas, β-cells release only 5% of their insulin content in an ...

Human beta cell mass and function in diabetes - ScienceDirect.com

Type 1 diabetes (T1D) is a chronic autoimmune disorder in which the immune system attacks endogenous pancreatic beta cells resulting in insulin deficiency, ...

Pancreatic beta‐cell mass and function and therapeutic implications ...

The main pathophysiology of both type 1 diabetes and long-standing type 2 diabetes is pancreatic β-cell mass loss and dysfunction. According to ...

Pancreatic β-cells in type 1 and type 2 diabetes mellitus

New findings from studies performed on human β-cells or on samples obtained from patients with type 1 or type 2 diabetes mellitus are highlighted, ...

Pancreatic β-cells in type 1 and type 2 diabetes mellitus - Europe PMC

Over the past decade, major advances have been made in the field, mostly delivered by studies on β-cells in human disease. ... Here, we review these new findings, ...

Pancreatic β-cells in type 1 and type 2 diabetes mellitus

... 1 Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are the two main types of DM and are characterized by the loss and dysfunction of ...