Pancreatic Beta|cell Dysfunction in Type 2 Diabetes

Pancreatic β-cell dysfunction in type 2 diabetes - PubMed Central

Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes (T2D).

Pancreatic Beta-cell Dysfunction in Type 2 Diabetes - Sage Journals

Recent evidence has suggested that β-cell dysfunction is the main pathogenic mechanism of diabetes and is crucial for T2DM development. In ...

Beta Cell Dysfunction and Insulin Resistance - PMC - PubMed Central

As beta cell dysfunction and insulin resistance exacerbate, hyperglycemia amplifies leading to the progression to type 2 diabetes (Figure 1). This review ...

Pancreatic β-cells in type 1 and type 2 diabetes mellitus - Nature

Pancreatic β-cell dysfunction and cell death are key processes in the development of type 1 diabetes mellitus (T1DM) and type 2 diabetes ...

β-cell secretory dysfunction: a key cause of type 2 diabetes

Correspondence. β-cell secretory dysfunction: a key cause of type 2 diabetes – Authors' reply. Weir et al. The Lancet Diabetes & EndocrinologyMay, 2020.

Full article: Beta-cell failure in type 2 diabetes: mechanisms, markers ...

In conclusion, significant beta-cell dysfunction is likely in individuals with certain clinical characteristics of T2D, such as long duration of disease, high ...

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 ...

Chronic exposure to elevated levels of glucose and free fatty acids (FFAs) causes β-cell dysfunction and may induce β-cell apoptosis in type 2 diabetes.

Reversing pancreatic β-cell dedifferentiation in the treatment of type ...

As a result, mitochondrial malfunction impairs GSIS and causes β-cell dysfunction. Chronic hyperglycemia increases rates of glycolysis, the TCA ...

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 ...

In individuals with type 2 diabetes, function within the sustained β cell volume further declines. These results indicate that dysfunction of ...

The Pathologic Basis of Reversible β-Cell Dysfunction | Diabetes Care

Recent postmortem studies demonstrate that β-cell dysfunction in type 2 diabetes may be associated with degranulation and alterations in the β- ...

Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes

Clinical Evidence of the β-Cell Dysfunction Role in T2D. Several epidemiological studies in adult populations have shown that β-cell malfunction is a sine qua ...

β Cell dysfunction during progression of metabolic syndrome to ... - JCI

... insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. ... pancreatic beta-cell dysfunction in diabetes mellitus.

Importance of β-Cell Failure in the Development and Progression of ...

A number of different hypotheses have been advanced as explanations for the development of β-cell dysfunction in type 2 diabetes. These include β-cell ...

Pancreatic Beta-cell Dysfunction in Type 2 Diabetes - ResearchGate

... Pancreatic Beta-cell Dysfunction in Type 2. Diabetes. Phyu Phyu Khin. 1. , Jong Han Lee. 3. and Hee-Sook Jun. 1,2,4.. Abstract. Pancreatic β ...

Insulin-Producing Beta Cells Are Not Irreversibly Lost in Early Type ...

Type 2 diabetes is a progressive disease over time, and previous research has suggested beta cell death is the root cause of increasing failure ...

Pancreatic β cells: Gatekeepers of type 2 diabetes

In T2D, increased metabolic stress due to hyperglycemia and peripheral insulin resistance can induce mitochondrial dysfunction, leading to ...

Pharmacological inhibitors of β-cell dysfunction and death ... - Frontiers

In type 2 diabetes (T2D), β-cell secretory dysfunction is a key event in the development of a clinically evident disease (5–8). A loss of β-cell mass by ...

Pancreatic Beta-cell Dysfunction in Type 2 Diabetes

Pancreatic Beta-cell Dysfunction in Type 2 Diabetes · Send item details · View online · From another institution · Details · Citations.

Clinical expert consensus on the assessment and protection of ...

Islet β-cell dysfunction is a basic pathophysiological characteristic of type 2 diabetes mellitus (T2DM). Appropriate assessment of islet β-cell function is ...

Its critical role in prevention and management of type 2 diabetes

Type 2 diabetes (T2DM) is characterized by insulin resistance and β-cell dysfunction. Although, in contrast to type 1 diabetes, insulin resistance is assumed to ...