Pathogenesis of systemic lupus erythematosus

Pathogenesis of systemic lupus erythematosus - PMC

An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved.

Pathogenesis of systemic lupus erythematosus: risks, mechanisms ...

This review describes recent data from genetic analyses of patients with SLE, along with current studies of innate and adaptive immune function.

The Pathogenesis of Systemic Lupus Erythematosus – An Update

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to ...

Systemic Lupus Erythematosus (SLE) - Medscape Reference

SLE is an autoimmune disorder characterized by multisystem inflammation with the generation of autoantibodies. Although the specific cause of ...

Systemic lupus erythematosus: Epidemiology and pathogenesis

Outline · SUMMARY · INTRODUCTION · EPIDEMIOLOGY · Incidence and prevalence · Sex · Age at onset · Geography and race/ethnicity · PATHOGENESIS.

Lupus | Pathogenesis and Pathophysiology - Healio

This is a continuing challenge in systemic lupus erythematosus (SLE), a chronic autoimmune disorder whose pathophysiology involves a complex ...

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular ...

Studies have identified local, organ-specific factors enabling or ameliorating SLE tissue damage, thereby dissociating autoimmunity and end-organ damage.

Systemic lupus erythematosus - predisposition factors, pathogenesis ...

Editorial on the Research Topic Systemic lupus erythematosus - predisposition factors, pathogenesis, diagnosis, treatment and disease models

Advances in the Pathogenesis and Treatment of Systemic Lupus ...

The pathogenesis of SLE is complex and involves cells of both innate and adaptive immunity. The distinguishing feature of SLE is the production of ...

Pathogenesis of systemic lupus erythematosus

An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved.

An Overview of Systemic Lupus Erythematosus (SLE) Pathogenesis ...

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement. It is multifactorial and involves ...

New insights into the immunopathogenesis of systemic lupus ...

The pathogenesis of SLE hinges on loss of tolerance and sustained autoantibody production (Fig. 1). Unlike self-limited autoantibody processes, ...

Immunometabolism in the pathogenesis of systemic lupus ...

SLE is characterized by immune system activation, including autoantibody synthesis, immune complex accumulation and infiltration of proinflammatory cells [14].

Self-dsDNA in the pathogenesis of systemic lupus erythematosus

In this review, we will discuss the potential resources of self-dsDNA, the mechanisms of self-dsDNA-mediated inflammation through various DNA sensors and its ...

Cellular and molecular pathogenesis of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex disease characterized by the appearance of autoantibodies against nuclear antigens and the ...

Immunological pathogenesis and treatment of systemic lupus ...

Breakdown of self-tolerance is the main pathogenesis of SLE. The innate and adaptive immune networks are interlinked with each other through ...

Disentangling the Pathogenesis of Systemic Lupus Erythematosus

In this review, we will discuss the molecular and cellular aspects of SLE pathogenesis, with a focus on how the immune system, genetics and the environment ...

Genetics and pathogenesis of systemic lupus erythematosus and ...

This Review discusses the genetic insights and molecular mechanisms for key pathogenic contributors in SLE and lupus nephritis.

Pathogenesis of Systemic Lupus Erythematosus - SpringerLink

Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune- ...

Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond

Autoreactive B cells and interferons are central players in systemic lupus erythematosus (SLE) pathogenesis. The partial success of drugs ...