Patient|Derived Cancer Organoids as Predictors of Treatment ...

Patient-Derived Cancer Organoids as Predictors of Treatment ...

Patient-derived cancer organoids have taken a prominent role in pre-clinical and translational research and have been generated for most ...

Patient-derived organoids as a predictive biomarker for treatment ...

Effective predictive biomarkers are needed to enable personalized medicine and increase treatment efficacy and survival for cancer patients, ...

Patient-Derived Cancer Organoids: Predictors of Treatment ...

Patient-derived organoids (PDO) are based on advanced three-dimensional (3D) culture technology and closely resemble original patient tumors.

Patient-Derived Tumor Organoids Can Predict the Progression-Free ...

Recent studies have shown patient-derived tumor organoids can predict the drug response of patients with cancer. However, the prognostic value of patient- ...

Patient-derived tumor organoids for prediction of cancer treatment ...

Biobanks of patient-derived cancer organoids have the potential to be accessible worldwide to advance research and treatment. Since organoid cultures mimic the ...

The Efficacy of Using Patient-Derived Organoids to Predict ... - MDPI

Patient-derived tumour organoids are three-dimensional models of patients' cancer cells which can be tested for sensitivity to various treatment options in the ...

Patient-derived tumor organoids: a new avenue for preclinical ...

PDTO panels can also be used to define predictive molecular signatures (genomic, transcriptomic, and proteomic signatures) of treatment response ...

Review Patient-derived organoids in precision cancer medicine

The generation of patient-derived organoids (PDOs) from various human cancers allows for deeper insights into tumor heterogeneity and spatial ...

Patient-Derived Cancer Organoids as Predictors of Treatment ...

Cancer organoids have been shown to retain key genetic and phenotypic characteristics of their tissue of origin, tumor subtype and maintain ...

Unified framework for patient-derived, tumor-organoid-based ...

Predictive drug testing of patient-derived tumor organoids (PDTOs) holds promise for personalizing treatment of metastatic colorectal cancer ...

Advancing Cancer Therapy Predictions with Patient-Derived ... - MDPI

We treated the tumor organoids to implement a reliable application for drug screenings of metastasized cells. Drug assays revealed that responses are not always ...

Patient-derived organoids can predict response to chemotherapy in ...

We developed an in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify nonresponders to standard-of-care ...

Patient-derived organoids in precision cancer medicine: Med

Thus, PDOs serve as valuable tools to study several aspects of tumor biology and can enhance the predictive accuracy of drug efficacy ...

Patient-derived organoids model treatment response of metastatic ...

Phenotypic and genotypic profiling of PDOs showed a high degree of similarity to the original patient tumors. Molecular profiling of tumor ...

Patient-derived organoids in human cancer: a platform for ...

In contrast to conventional models, tumor organoids offer an intuitive, dependable, and efficient in vitro research model by conserving the ...

The TRIPLEX study: use of patient-derived tumor organoids as an ...

Despite the frequent use of this combination for TNBC treatment, moderate results are observed and its clinical benefit in TNBC remains ...

Organoids for Functional Precision Medicine in Advanced ...

Patient-derived organoids (PDOs) are promising tumor avatars that could enable ex vivo drug tests to personalize patients' treatments in the frame of ...

Patient-derived organoids for precision oncology - BMC Cancer

Mechanisms of drug or therapy resistance include involvement of cancer-associated fibroblasts (CAFs) in driving synthesis and cross-linking of ...

Patient-Derived Cancer Organoids as Predictors of Treatment ...

Cancer organoids have been shown to retain key genetic and phenotypic characteristics of their tissue of origin, tumor subtype and maintain intratumoral ...

[PDF] Patient-derived organoids model treatment response of ...

Responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical ...