Patient|Derived Organoids

Patient-derived organoids as a predictive biomarker for treatment ...

Effective predictive biomarkers are needed to enable personalized medicine and increase treatment efficacy and survival for cancer patients, ...

Patient-derived organoids: a promising model for personalized ...

Patient-derived organoids: a promising model for personalized cancer treatment. Huayu Yang Huayu Yang 1 Department of Liver Surgery, Peking Union Medical ...

Patient-derived Organoids, Tumoroids - Molecular Devices

Patient-derived tumor organoids or tumoroids are cultures of tumor cells derived from individual patients and have transformed the field of drug and target ...

Patient-derived tumor organoids: a new avenue for preclinical ...

Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has broadened the repertoire of preclinical models and ...

Patient-derived organoids in translational oncology and drug ...

Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct phenotypic and genetic characteristics of the ...

Patient-derived organoids for precision oncology - BMC Cancer

We report development of a novel integrated platform to facilitate clinical decision-making using the patient's primary cells, iPSCs and derivatives.

Patient-derived organoids in translational oncology and drug ...

Abstract. Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct phenotypic and genetic characteristics of the ...

Unlocking the potential of patient-derived organoids ... - UCLA Health

UCLA investigators have developed the largest collection of sarcoma patient-derived organoids to date that can help improve the ...

Patient-derived organoids in precision cancer medicine: Med

This review covers aspects of PDO cultures to address the modeling of the tumor microenvironment, including extracellular matrices, air-liquid interface and ...

Organoids - ATCC

In collaboration with the Human Cancer Models Initiative (HCMI), we offer patient-derived organoids as models to study the behavior of cancer.

Clinical translation of patient-derived tumour organoids- bottlenecks ...

In this review, we identify the major bottlenecks preventing patient-derived tumour organoids (PDTOs) from being used in clinical setting.

Patient‐Derived Organoids as Therapy Screening Platforms in ...

Patient-derived organoids (PDOs) are three-dimensional (3D) cell cultures obtained from patient tissues (Figure 1). ... These are produced by ...

Patient-Derived Organoids in Precision Medicine: Drug Screening ...

In this review, we highlight recent developments in the generation of organoid cultures and PDO biobanks, in preclinical drug discovery, and methods to design ...

Druggable Growth Dependencies and Tumor Evolution Analysis in ...

established patient-derived tumor organoids (PDTOs) from neuroendocrine neoplasms including low-grade pulmonary neuroendocrine tumors. Multi- ...

Patient-derived head and neck cancer organoids allow treatment ...

We present a diverse biobank of organoids derived from patients with HNC that phenotypically and genetically recapitulate the original tissue they are derived ...

Patient-derived organoids in human cancer: a platform for ...

This review extensively examines the use of tumor organoid techniques in fundamental research and precision medicine.

Patient‐Derived Organoids Can Guide Personalized‐Therapies for ...

Personalized therapies are urgently needed for patients with advanced breast cancers. Patient-derived organoids (PDOs) can be generated from ...

Patient-derived organoids model treatment response of metastatic ...

We report on a living biobank of PDOs from metastatic, heavily pretreated colorectal and gastroesophageal cancer patients recruited in phase 1/2 clinical ...

Patient-derived organoids can predict response to chemotherapy in ...

We developed an in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify nonresponders to standard-of-care ...

Patient-derived organoids as a platform for drug screening in ...

The PDO model is an effective platform for in vitro assessment of patient-specific drug sensitivity, which can guide personalized treatment decisions.