Penn researchers identify key mechanism of kidney disease

Penn Researchers Identify Key Mechanism of Kidney Disease

Penn researchers identify changes in NAD metabolism in both mouse and human kidneys; findings could lead to new drugs to prevent and treat ...

The study was conducted by co-lead investigators Katalin Susztak, professor of nephrology and co-chair of the Kidney Innovation Center at Penn ...

Scientists identify key pathway underlying kidney disease

A new study using kidney samples from humans and mice suggests that NAD deficiency plays a central role in mediating inflammation and metabolic ...

Penn Researchers Unlock Genetic 'Treasure Map' for Chronic ...

Though diabetes and high blood pressure play key roles in chronic kidney disease development, the disease has a strong heritable component, and ...

Developing kidneys from scratch - Penn Today

Bioengineering professor Alex Hughes tackles the burden of chronic kidney disease by creating kidney tissue from scratch, which could reduce ...

Researchers tackle the tremendous burden of kidney disease

Unfortunately, kidneys struggle in the modern world. Excessively salty food, being overweight, not exercising enough, drinking too much and ...

New research maps possible molecular origins of kidney disease

Penn scientists have identified more than 500 genes associated with kidney disease that could be therapeutic targets.

Kidney Disease Therapeutic Target IDed by UPenn Team

A team of researchers has identified the enzyme NAD as a new therapeutic target and biomarker indicative of kidney disease.

New Knowledge About Kidney Function and Related Hypertension

University of Pennsylvania researchers identify 182 genes responsible for kidney function and 88 genes associated with hypertension related to the kidneys.

Pioneering Single Cell Kidney Atlas Developed by Children's ...

Key findings include identification of 44 main and 114 distinct cell sub-types or states in both healthy and CKD-affected human kidneys. The ...

Nearly 200 Kidney Function Genes Identified as Part of Genetic ...

Although diabetes and high blood pressure play key roles in chronic kidney disease development, the disease has a strong heritable component, ...

Synergy in Science: Introducing the Penn-CHOP Kidney Innovation ...

Though pediatric and adult kidney disease have unique qualities and key differences, they can nonetheless inform each other and this is where ...

Developing Precision Medicine for Chronic Kidney Disease

In a genome-wide association study, Perelman School of Medicine at the University of Pennsylvania researchers identified 182 genes ...

Genetic Insights into Blood Pressure From Kidney Multi-Omics

Pennsylvania; and Penn/CHOP Kidney Innovation Center,. University of ... of human traits to cell types in the kidney identifies mechanisms of disease ...

Molecular mechanisms of diabetic kidney disease - PMC

Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the single strongest predictor of mortality in patients with diabetes.

Kebin Hu - Penn State Research Database

The hallmark of chronic kidney disease (CKD) is renal interstitial fibrosis and inflammation, which is characterized by proliferation and activation of ...

Cosmic kidney disease: an integrated pan-omic, physiological and ...

The kidney is a plastic organ, and is capable of dynamically remodelling the architecture of the nephron in response to changes in blood ...

THE NEXT GENERATION OF THERAPEUTICS FOR CHRONIC ...

Chronic kidney disease (CKD) represents a leading cause of death in the United States. There is no cure for the disease, with current treatment strategies ...

Key Mechanism for Kidney Disease Identified. Penn Medicine ...

Key Mechanism for Kidney Disease Identified. Penn Medicine scientists uncovered protective role of NAD maintenance in kidney disease, ...

Chronic Renal Disease | Department of Health

End-stage renal disease is a condition in which the kidneys no longer function normally. Usually, in end-stage renal disease, the kidneys are functioning at ...