Pentameric Ligand|Gated Ion Channels as Pharmacological Targets ...

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets ...

The pharmacological modulation of pentameric ligand-gated ion channels is a promising strategy towards the development of novel therapeutics to treat chronic ...

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets ...

Collectively, these evidences strongly suggest the pharmacological modulation of pentameric ligand-gated ion channels is a promising strategy ...

Open-channel structure of a pentameric ligand-gated ion ... - Nature

Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment.

An update on how pentameric ligand-gated ion channels interact ...

Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several ...

A gating mechanism of pentameric ligand-gated ion channels - PNAS

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communication in the nervous system and are involved in fundamental processes ...

Insights and Incongruities in Pentameric Ligand-gated Ion Channel ...

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in electrochemical signal transduction across evolution, ...

Regulation of a pentameric ligand-gated ion channel by a ...

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from ...

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand ...

Ligand-gated ion channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G ...

Gating of Pentameric Ligand-Gated Ion Channels: Structural Insights ...

Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic communication by converting chemical signals into an electrical response.

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

For both ligand and voltage gated targets, the most recent decade has shown a large increase in clinical compounds that target single channel ...

Drug Discovery on Pentameric Ligand-Gated Ion Channels

Pentameric ligand-gated ion channels (pLGICs) are extensively involved in fast synaptic transmission and play a key role in many different ...

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

However, the prokaryotic ancestors of these receptors contain no such loop and the term pentameric ligand-gated ion channel (pLGIC) is gaining ...

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion ...

Here, we review such lipid-drug binding sites, focusing on pentameric ligand-gated ion channels and transient receptor potential channels.

Molecular tuning of fast gating in pentameric ligand-gated ion ...

Pentameric ligand-gated ion channels (LGICs), such as the cationic nicotinic acetylcholine receptor (nAChR) and the anionic glycine receptor (GlyR), mediate ...

Chasing the open-state structure of pentameric ligand-gated ion ...

In the case of the superfamily of nicotinic-receptor channels (also referred to as pentameric ligand-gated ion channels [pLGICs]), for example, two different ...

Ligand-gated ion channels

The LGICs thus present attractive targets for new therapeutic agents with improved discrimination between receptor isoforms and a reduced propensity for off- ...

Vestibular Modulation by Stimulant Derivatives in a Pentameric ...

Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) is critical to the action of neurotransmitters and many psychoactive ...

3 - Ion Channels as Targets of Psychopharmacological Drug Action

The subunits for pentameric subtypes of ligand-gated ion channels each have four transmembrane regions (Figure 3-2A). These membrane proteins go in and out of ...

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets ...

Details · Title. Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain · Published In. Frontiers in pharmacology, 2020-03, Vol.11, ...

Allosteric Transitions of Pentameric Ligand-Gated Ion Channels ...

Pentameric ligand-gated ion channels (pLGICs) are membrane receptors found in both prokaryotes, like GLIC, and eukaryotes.