Pericancerous cross|presentation to cytotoxic T lymphocytes impairs ...

Pericancerous cross-presentation to cytotoxic T lymphocytes impairs ...

Herein, our study reveals that pericancerous macrophages cross-present antigens to CD103+ CTLs in hepatocellular carcinoma (HCC) via the ...

Pericancerous cross-presentation to cytotoxic T lymphocytes impairs ...

Cancer Cell, Volume 42. Supplemental information. Pericancerous cross-presentation to cytotoxic. T lymphocytes impairs immunotherapeutic efficacy in ...

Dendritic cell cross‐dressing and tumor immunity - PMC - NCBI

In addition to direct and cross‐presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly ...

Cytotoxicity as a form of immunogenic cell death leading to efficient ...

The cross-presentation of tumor antigens to cross-prime CD8+ T cells is mainly mediated, if not only, by a subset of professional antigen- ...

Current Concepts of Antigen Cross-Presentation - Frontiers

Peptides loaded onto MHC II molecules can be recognized by antigen-specific CD4+ T helper cells. Similarly, peptides loaded on MHC I molecules can be recognized ...

Cross-Presentation - an overview | ScienceDirect Topics

Cross presentation is the capacity of an antigen-presenting cell to acquire exogenous antigen and present the processed peptides in the context of MHC-I.

Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity

cDC1s are superior in antigen cross-presentation, a process of presenting exogenous antigens on MHC class I to activate CD8+ T cells. Tumor- ...

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in ...

To determine whether a specific subset of splenic DCs is involved in this cross-presentation, we negatively and positively selected for CD8− and CD8+ DCs. Only ...

Cross priming or direct priming: is that really the question?

In this review, we focus exclusively on antigen presentation during the induction of immunity mediated by CD8+ T cells in vivo. The induction of tolerance — ...

Dendritic cells in cancer immunology | Cellular & Molecular ... - Nature

Second, we cover work in the area of cDC1 antigen processing of tumor antigens that can be recognized by CD8 T cells, called cross-presentation.

Impaired dendritic cell functions in lung cancer: a review of recent ...

This IFN has been shown to participate in cytotoxic, immunosuppressive, and anti-tumor responses [53, 54]. The activation of intratumoral pDCs ...

Lipid bodies containing oxidatively truncated lipids block antigen ...

Cross-presentation is a critical function of dendritic cells (DCs) required for induction of antitumor immune responses and success of ...

Adaptation of the Tumor Antigen Presentation Machinery to Ionizing ...

Of particular interest is its effect on MHC class I (MHC-I)–directed, Ag-specific CD8+ T cell responses that are critical for tumor immunity (2– ...

Next-generation antigen-presenting cell immune therapeutics ... - JCI

MHC class I–mediated presentation of antigens (Ags) is fundamental to activation of granzyme- and perforin-producing cytotoxic CD8+ T cells.

Dendritic cell biology and its role in tumor immunotherapy

T cell microvillar dynamics and TCR conformational changes were demonstrated upon DC antigen presentation. Caspase-11-driven hyperactive DCs ...

Decoupled neoantigen cross-presentation by dendritic cells limits ...

Cytotoxic CD8+ T cells recognize peptides on class I major histocompatibility complexes (MHCI) expressed on tumor cells, and following ...

Antigen cross-presentation and T-cell cross-priming in cancer ...

Mounting evidence suggests that antigen transfer to DCs and their surrogate presentation on major histocompatibility complex class I and II ...

Aging Impairs the Ability of Conventional Dendritic Cells to Cross ...

Taken together, our results suggest that immunosenescence impacts cDC function, affecting the activation of naïve CD8+ T cells and the generation of effector ...

Cross-presentation of a TAP-independent signal peptide induces ...

Cancer cells frequently display defects in their antigen-processing pathway and thereby evade CD8 T cell immunity. We described a novel ...

MHC Class I Antigen Processing and Presenting Machinery

The surface presentation of peptides by major histocompatibility complex (MHC) class I molecules is critical to all CD8 + T-cell adaptive immune responses, ...