Perspective Targeting BCL|2 in B|cell lymphomas

Targeting BCL-2 in B-cell lymphomas - PubMed

The B-cell leukemia/lymphoma-2 (BCL-2) family of proteins governs the intrinsic pathway of mitochondrial apoptosis. Dysregulation of BCL-2 ...

Perspective Targeting BCL-2 in B-cell lymphomas - ScienceDirect.com

Conclusions. The recent approval of venetoclax has demonstrated that BCL-2 inhibition is an important new approach in treating B-cell lymphomas.

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic ...

Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins are key regulators of the intrinsic, mitochondrial apoptotic pathway.

Targeting the Bcl-2 Family in B Cell Lymphoma - Frontiers

Although lymphoma is a very heterogeneous group of biologically complex malignancies, tumor cells across all B cell lymphoma subtypes share a set of ...

Targeting the Bcl-2 Family in B Cell Lymphoma - PubMed

Although lymphoma is a very heterogeneous group of biologically complex malignancies, tumor cells across all B cell lymphoma subtypes share ...

B-cell lymphoma 2 family members and sarcomas

Targeting the B-cell lymphoma 2 (Bcl-2) family proteins has been the backbone for hematological malignancies with overall survival improvements.

[PDF] Targeting BCL-2 in B-cell lymphomas. | Semantic Scholar

... BCL-2-selective therapy and how to overcome resistance. Finally, I provide my perspective on how to move BCL-2-directed therapies forward toward a goal of ...

Targeting BCL2 for the Treatment of Lymphoid Malignancies

... targeting BCL2 as a novel approach to treating various hematologic malignancies. ... targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem, 46 (2003), pp ...

Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives

... lymphoma, particularly diffuse large B-cell lymphoma [99]. Functional analysis revealed that some of these mutations (BCL-2 G33R or A43T) markedly increased BCL ...

B-cell lymphoma 2 (Bcl-2) protein family

... cell proliferation [6]. Prosurvival Bcl-2 family proteins are therefore tractable drug targets for the development of novel anti-cancer therapies, as well ...

Specific interactions of BCL-2 family proteins mediate sensitivity to ...

BCL-2, BCL-XL and MCL-1 are important therapeutic targets in diffuse large B-cell lymphoma. To investigate the roles of the main anti ...

Targeting BCL-2 in B-cell lymphomas - ResearchGate

Finally, I provide my perspective on how to move BCL-2-directed therapies forward toward a goal of developing well-tolerated, time-limited combination regimens ...

B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer ...

... approach for analyzing the molecular systems that trigger tumor cell growth. The examination of the t(14:18) translocation breakpoint and the finding of the Bcl ...

Targeting the Bcl-2 Family in B Cell Lymphoma | Semantic Scholar

... targeted approach directed against alternative antiapoptotic BCL-2 family proteins, compensatory prosurvival pathways, epigenetic modifiers, and ...

Dual targeting of the DNA damage response pathway and BCL-2 in ...

Standard chemotherapies for diffuse large B-cell lymphoma (DLBCL), based on the induction of exogenous DNA damage and oxidative stress, ...

BCL2-Family Dysregulation in B-Cell Malignancies - Frontiers

Targeting BCL-2 in B-cell lymphomas. Blood (2017) 130:1081–8. doi: 10.1182 ... 33,199 views; 12 citations. Original Research. Published on 12 Mar 2021 ...

BCL-2 protein family: attractive targets for cancer therapy | Apoptosis

... Targeting the Bcl-2 Family in B Cell Lymphoma. Front Oncol 8:636 ... Targeting MCL-1 in cancer: current status and perspectives. J ...

BCL-2 as therapeutic target for hematological malignancies

... [2, 3]. The members of the B-cell lymphoma-2 (BCL-2) family are central regulators of apoptosis triggered by environmental cues and in ...

Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell ...

B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the mitochondrion. It remains a challenge to identify those tumors that ...

Targeting BCL-2 regulated apoptosis in cancer | Open Biology

Recent pharmaceutical advances have allowed the specific targeting of protein–protein interactions in the BCL-2 (B-cell lymphoma 2) family [2–4] ...