Pharmacogenetics at scale

Pharmacogenetics at Scale: An Analysis of the UK Biobank - PubMed

Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the ...

Pharmacogenetics at Scale: An Analysis of the UK Biobank

Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines ...

Pharmacogenetics at Scale: An Analysis of the UK Biobank - McInnes

Abstract. Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform ...

Pharmacogenomics at scale : population analysis and machine ...

Pharmacogenomics promises the ability to provide personalized therapeutic guidance for patients based on their genetics.

Pharmacogenetics at scale in real-world bioresources

This study utilizes the UK Biobank dataset, including 10 365 patients treated with clopidogrel, to offer the largest observational analysis of these ...

Pharmacogenetics at scale: An analysis of the UK Biobank - bioRxiv

We analyzed haplotype and phenotype allele frequencies in clinically important pharmacogenes among individuals belonging to four global ...

Pharmacogenetics at Scale: An Analysis of the UK Biobank.

PharmGKB annotates drug labels containing pharmacogenetic information from multiple drug regulatory agencies. Labels from the FDA, EMA and HCSC are updated ...

Pharmacogenetics at scale: An analysis of the UK Biobank

For fourteen CPIC pharmacogenes known to influence human drug response, it is found that 99.5% of individuals may have an atypical response to at least one ...

Pharmacogenetics at scale: An analysis of the UK Biobank

We used nearly 500,000 genotypes and 50,000 exome sequence samples in the UK Biobank to analyze pharmacogenetic variation at a population scale.

Leveraging large-scale biobank EHRs to enhance ... - NCBI

In summary, we systematically investigated the common and rare pharmacogenetic contribution to cardiometabolic drug response phenotypes in over 50,000 UK ...

CYP2C19 and clopidogrel outcomes in UK Biobank — Discovery

However, there is a scarcity of large-scale real-world data on the extent of this pharmacogenetic effect, and clinical testing for the CYP2C19 genotype remains ...

Pharmacogenetics at Scale: An Analysis of the UK Biobank

... [7][8][9] The UK Biobank Project, a prospective cohort study that collected phenotypic frequencies for 14 genes in 487 409 individuals, found that 99.5% of ...

Pharmacogenetics at scale: An analysis of the UK Biobank - OUCI

Michelle Whirl-Carrillo; Russ B. Altman. Abstract. AbstractPharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically ...

CYP2C19 and clopidogrel outcomes in UK Biobank - ResearchGate

Request PDF | Pharmacogenetics at scale in real-world bioresources: CYP2C19 and clopidogrel outcomes in UK Biobank | Objective The impact of CYP2C19 ...

Frequencies of pharmacogenomic alleles across biogeographic ...

In this study, we performed a comprehensive estimation of PGx frequencies by taking advantage of the large-scale genetic UK Biobank. Using the Pharmacogenomics ...

Large-scale next generation sequencing based analysis of ...

Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population. Ewa Goljan,; Mohammed ...

Biobank scale pharmacogenomics informs the genetic ... - medRxiv

We used biobank-scale data to uncover and replicate a novel association between NAT2 locus variation (and suggestive evidence with several other genes) and ...

Clinical pharmacogenetic analysis in 5,001 individuals with ... - Nature

Exome sequencing is utilized in routine clinical genetic diagnosis. The technical robustness of repurposing large-scale next-generation ...

Evaluating the frequency and the impact of pharmacogenetic alleles ...

... pharmacogenetics implementation consortium and dutch pharmacogenetics working group. ... Pharmacogenetics at scale: an analysis of the UK Biobank.

Leveraging large-scale biobank EHRs to enhance ... - medRxiv

In summary, we systematically investigated the common and rare pharmacogenetic contribution to cardiometabolic drug response phenotypes in over ...