Pharmacogenomics Beyond Single Common Genetic Variants

Interindividual variability in genes encoding drug-metabolizing enzymes, transporters, receptors, and human leukocyte antigens has a major ...

Pharmacogenomics Beyond Single Common Genetic Variants ... In this Collection, we invite original research articles, case reports, meta-analyses, and reviews that ...

Pharmacogenomics Beyond Single Common Genetic Variants

Pharmacogenetics investigates sequence of genes that affect drug response, enabling personalized medication. This approach reduces drug-induced adverse ...

Pharmacogenomics Beyond Single Common Genetic Variants

During the 1980s and 1990s, important and com- mon genetic variations were found in multiple genes encoding drug-metabolizing enzymes and drug ...

Emerging trends in pharmacogenomics: from common variant ...

Since the identification of the first pharmacogenetic variants more than 30 years ago, more than 69,000 distinct single nucleotide variants ( ...

Identification and functional validation of novel pharmacogenomic ...

Inter-individual variability in pharmacokinetics and drug response is heavily influenced by single-nucleotide variants (SNVs) and copy-number variations ...

Estimating the efficacy of pharmacogenomics over a lifetime - NCBI

It is well known that common variants in specific genes influence ... one or more of these common variants (3–5). For example, the ...

Genetic ancestry in population pharmacogenomics unravels distinct ...

manually curated reports) for a subset of single nucleotide variants (SNVs) (n = 200) corresponding to multiple drugs, randomly selected among hundreds of ...

Translating pharmacogenomic sequencing data into drug response ...

Applied to pharmacogenomics, this means that commonly used algorithms that are trained on pathogenic variants are not well suited for ...

Pharmacogenetic Variant - an overview | ScienceDirect Topics

Pharmacogenomics describes the influence of genetic variation on any aspect of drug response. The heritability of such phenotypes for psychiatric medications is ...

Pharmacogenomics and Personalized Medicine - Nature

When a gene variant is associated with a particular drug response in a patient, there is the potential for making clinical decisions based on genetics by ...

Pharmacogenomics - The Lancet

Such bioactivation pathways usually involve a single drug-metabolising enzyme and genetic variants that result in loss of function of these ...

Pharmacogenomics: Better drugs through better screening - Science

Finding the connections between genetic variants and drugs, understanding their mechanisms of action, and learning how to mitigate, manipulate, circumvent, and ...

Beyond drugs: the evolution of genes involved in human response ...

In recent years, developments in DNA sequencing technologies enabled the transition from the candidate-gene approach typical of pharmacogenetics ...

APF2: an improved ensemble method for pharmacogenomic variant ...

Pharmacogenomics Beyond Single Common Genetic Variants: The Way Forward. ... Integrating rare genetic variants into pharmacogenetic drug ...

Pharmacogenomics of anticancer drugs: Personalising the choice ...

Many of these gene–drug interactions are the fruits of candidate gene and genome-wide association studies, which have largely focused on common ...

How is pharmacogenomics being used beyond cancer?

An area of genomics that studies how individuals react to drug treatments - a form of personalised medicine. Gene. A section of DNA within a genome that carries ...

Opportunities and Challenges in Cardiovascular Pharmacogenomics

Thus, candidate gene and unbiased methods such as genome-wide association studies (GWAS) have more commonly been used to define genes ...

Pharmacogenomics Beyond Single Common Genetic Variants

Pharmacogenomics Beyond Single Common Genetic Variants: The Way Forward-article.

Pharmacogenetics vs Pharmacogenomics - Precision Life Sciences

Instead of focusing solely on singular genetic variations and their direct drug correlations, pharmacogenomics investigates the collective ...