Pharmacologic IRE1/XBP1s activation promotes systemic adaptive ...

Our findings indicate that systemic, transient activation of IRE1/XBP1s signaling engenders multi-tissue benefits that integrate to mitigate obesity-driven ...

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive ...

Further, we show that IXA4 treatment also improved insulin regulation and secretion in the pancreas, revealing a new mechanism through which ...

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive ...

In obesity, overexpression of the IRE1-regulated transcription factor XBP1s protects against metabolic dysfunction by stimulating adaptive ...

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER ...

Thus, IRE1 activation can promote adaptive remodeling that alleviates ER stress and enhances ER proteostasis through XBP1 splicing and/or RIDD. Increasing IRE1/ ...

Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive ...

PDF | In obesity, overexpression of the IRE1-regulated transcription factor XBP1s protects against metabolic dysfunction by stimulating adaptive.

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Aparajita Madhavan,; Bernard P. Kok,; Bibiana Rius,; Julia M. D. Grandjean ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive ...

In obesity, overexpression of the IRE1-regulated transcription factor XBP1s protects against metabolic dysfunction by stimulating adaptive remodeling of ...

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER ...

High selective activators of IRE1/XBP1 splicing pathway were identified via high-throughput screen, which promoted the degradation of APP and reduced ...

Scripps Research scientists unveil promising new approach to ...

“ Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity” was co-authored by Aparajita Madhavan, Bernard Kok ...

IRE1/XBP1 and endoplasmic reticulum signaling - ScienceDirect.com

Saez, et al. Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat Commun, 13 (2022), pp. 1-9. (2022 131).

IXA4 compound could be promising approach to diabetes prevention

The findings were reported in the paper, 'Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity', published in ...

Kaempferol attenuates particle-induced osteogenic impairment by ...

16. Madhavan, A. ∙ Kok, B.P. ∙ Rius, B. ... Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat. Commun. 2022; 13:608.

Pharmacologic IRE1/XBP1s activation confers targeted ER ... - OUCI

Chen, J. J., Genereux, J. C. & Wiseman, R. L. Endoplasmic reticulum quality control and systemic ... Activation of the unfolded protein response enhances motor ...

Regulation of the Homeostatic Unfolded Protein Response in ... - MDPI

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat. Commun. 2022, 13, 608. [Google Scholar] [CrossRef] ...

Reshaping endoplasmic reticulum quality control through the ...

71. Madhavan, A. ∙ Kok, B.P. ∙ Grandjean, J.M.D. ... Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.

X-box Binding Protein 1: An Adaptor in the Pathogenesis of ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat Commun, 13:608. [181]. Ferri E , Le Thomas A , Wallweber HA , Day ...

Myeloid XBP1 links lipid overload with inflammation in NASH

6. Madhavan, A. ∙ Kok, B.P. ∙ Rius, B. ... Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat Commun ...

Reshaping endoplasmic reticulum quality control through the ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Preprint at bioRxiv (2020), 10.1101/2020.12.03.408716.

The IRE1α-XBP1 pathway regulates metabolic stress-induced ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Aparajita Madhavan; Bernard P. Kok; R. Luke Wiseman.

Genomic targets of the IRE1-XBP1s pathway in mediating metabolic ...

Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation ... Activation of this cellular stress response enhances ECM secretion ...