Phosphoprotein Phosphatase 2

Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. ... The PP2A heterotrimeric protein phosphatase is ...

Phosphatase: PP2A structural importance, regulation and its ...

Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many ...

Phosphoprotein Phosphatase 2A - an overview | ScienceDirect Topics

Abstract. Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase. This enzyme is involved in a plethora of cellular processes, including ...

Phosphoprotein Phosphatase 2A - an overview | ScienceDirect Topics

PP2A is a diverse, multi-component enzyme complex involved in many aspects of cellular function. The multiple isoforms of each PP2A subunit, which combine to ...

PPP2CA protein phosphatase 2 catalytic subunit alpha [ (human)]

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the ...

Serine/threonine-protein phosphatase 2A catalytic subunit ... - UniProt

Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, ...

Crystal structure of a protein phosphatase 2A heterotrimeric ... - Nature

Here we report the crystal structure of an AB′C heterotrimeric PP2A holoenzyme. The structure reveals that the HEAT repeats of the scaffold A ...

Protein phosphatase 2A is crucial for sarcomere organization in ...

Abstract. Protein phosphatase 2A (PP2A) is a heterotrimer composed of single catalytic and scaffolding subunits and one of several possible ...

Ppp2ca - Serine/threonine-protein phosphatase 2A catalytic subunit ...

Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, ...

Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor ...

The serine/threonine phosphatase protein phosphatase 2A (PP2A) plays an essential role in many aspects of cellular functions and has.

Protein phosphatase 2A (PP2A): a key ... - Respiratory Research

We explain how dysregulation of PP2A in COPD creates a favourable inflammatory micro-environment and promotes the initiation and progression of tumour ...

Carboxyl methylation regulates phosphoprotein phosphatase 2A by ...

PP2A is a multimeric protein that has been highly conserved during the evolution of eukaryotes. The 36 kDa catalytic C subunit is found tightly associated with ...

Protein kinase A activates protein phosphatase 2A by ... - PNAS

We have elucidated a mechanism whereby protein phosphatase 2A (PP2A) is activated by a cAMP/PKA-dependent pathway, leading to dephosphorylation of Thr-75.

Targeting protein phosphatases for the treatment of inflammation ...

The phosphatase types vary according to their amino acid substrates and include the Tyr phosphatases, such as src homology-2 domain-containing ...

The biogenesis of active protein phosphatase 2A holoenzymes: a ...

In this review, we highlight how PP2A holoenzyme biogenesis and enzymatic activity are controlled by a sophisticatedly coordinated network of five PP2A ...

176915 - PROTEIN PHOSPHATASE 2, CATALYTIC SUBUNIT ...

Protein phosphatase 2A appears to play a role in the regulation of most major metabolic pathways, as well as translation, transcription, and control of ...

Small-Molecule Activation of Protein Phosphatase 2A Counters ...

The objective of this study was to determine whether the reactivation of PP2A could reduce fibrosis and preserve the pulmonary function in a bleomycin (BLM) ...

Protein phosphatase 2A – structure, function and role in ...

PP2A is responsible for at least 50% of total Ser/Thr dephosphorylation in most cell types and is predominantly found as trimeric holoenzymes ...

Protein phosphatase 2A dysfunction in Alzheimer's disease - Frontiers

“PP2A” dysfunction has been linked to tau hyperphosphorylation, amyloidogenesis and synaptic deficits that are pathological hallmarks of this neurodegenerative ...

Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging ...

CIP2A is a novel anticancer target based on PP2A reactivation and inhibition of the oncogenic activity of its downstream effectors.