Physiological Roles of Monomeric Amyloid|β and Implications for ...

Physiological Roles of Monomeric Amyloid-β and Implications for ...

Alzheimer's disease (AD) progressively inflicts impairment of synaptic functions with notable deposition of amyloid-β (Aβ) as senile plaques ...

Physiological Roles of Monomeric Amyloid-β and Implications for ...

A thorough review of manuscripts has revealed that Aβ may possess antimicrobial properties and play a role in regulating synaptic functions and memory. Also, Aβ ...

The Roles of the Amyloid Beta Monomers in Physiological ... - MDPI

Five main directions were proposed to explain the “protective” role of Aβ: antimicrobial effect, tumor suppressive activity, blood–brain barrier ...

Physiological Roles of Monomeric Amyloid-β and Implications for ...

However, the emerging evidence suggests that Aβ serves biological roles, which include suppressing microbial infections, regulating synaptic plasticity, ...

Role of monomeric amyloid-β in cognitive performance in ...

Monoclonal antibodies preferentially acting on aggregated forms of Aβ may improve cognitive performance of AD subjects through increasing soluble brain Aβ ...

Physiological Roles of β-amyloid in Regulating Synaptic Function

... amyloid-β ... Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology ... Exogenous Aβ1-42 monomers ...

Physiological Roles of Monomeric Amyloid-β and Implications for ...

Dive into the research topics of 'Physiological Roles of Monomeric Amyloid-β and Implications for Alzheimer's Disease Therapeutics'. Together they form a unique ...

A novel monomeric amyloid β-activated signaling pathway regulates ...

Amyloid β (Aβ) forms aggregates in the Alzheimer's disease brain and is well known for its pathological roles. Recent studies show that it also ...

Physiological and pathological effects of amyloid-β species in neural ...

The pathological function of amyloid-β peptide has been extensively studied due to its implication in Alzheimer's disease, but its physiological function ...

The physiological roles of tau and Aβ: implications for Alzheimer's ...

Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's disease (AD) and, as such, have become the focus of ...

Amyloid β-based therapy for Alzheimer's disease - Nature

Together, the possible role of Aβ peptide in the modulation of synaptic function as well as learning and memory has been suggested. Aβ monomers ...

A Novel Function of Monomeric Amyloid β-Protein Serving as an ...

Here, we show a novel function of monomeric Aβ1–40, which is the major species found in physiological fluid, as a natural antioxidant molecule ...

Physiological Role of Amyloid Beta in Neural Cells - IntechOpen

Aβ peptide has the ability of auto-aggregate, so it could exist as monomers, dimers or oligomers; which in turn can generate fibrils, that have β-sheet ...

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to ...

The presence of large numbers of “senile plaques” in the hippocampus and overlying cortical regions is one of the definitive features of Alzheimer's disease (AD) ...

Amyloid beta: structure, biology and structure-based therapeutic ...

Biological functions of Aβ. Aβ monomers can form higher order assemblies ranging from low molecular weight oligomers (including dimers, trimers, ...

The duality of amyloid-β: its role in normal and Alzheimer's disease ...

Aβ accumulation is also closely associated with other hallmark features of AD, underscoring its significance. Aβ is generated through cleavage ...

The Roles of the Amyloid Beta Monomers in Physiological ... - OUCI

Amyloid beta peptide is an important biomarker in Alzheimer's disease, with the amyloidogenic hypothesis as one of the central hypotheses trying to explain ...

Examining the Ensembles of Amyloid-β Monomer Variants and Their ...

The amyloid-β (Aβ) monomer, an intrinsically disordered peptide, is produced by the cleavage of the amyloid precursor protein, ...

Physiological levels of β-amyloid peptide promote PC12 cell ...

We have recently shown that nanomolar doses of Aβ can stimulate tyrosine phosphorylation and activate phosphatidylinositol-3-kinase in neuronal cells. Here we ...

Oligomerization and Conformational Change Turn Monomeric β ...

The structural polymorphism and the physiological and pathophysiological roles of two important proteins, β-amyloid (Aβ) and tau, that play a key role in ...