Plasma proteins reveal molecular signatures of aging and frailty

Scientists were able to uncover molecular signatures associated with particular life stages and predict accelerated aging and disease development.

Plasma protein-based organ-specific aging and mortality models ...

We then identify proteins driving these associations with organ-specific aging. Our analyses reveal that age-related chronic diseases epitomize ...

Plasma proteome profiling of healthy individuals across the life span ...

... plasma to reveal proteins that could be associated with healthy aging and longevity. ... age waves are unique to LLIs, suggesting a unique protein signature ...

Plasma proteomic profile of frailty - PMC

Pathway analysis with the top 143 frailty‐associated proteins revealed enrichment for proteins ... biology of frailty in aging. 2. RESULTS. 2.1. Study ...

Plasma-based organ-specific aging and mortality models unveil ...

This indicates that the chronological aging signature is enriched for proteins ... Severe COVID-19 is associated with molecular signatures of ...

Blog - Resources - Life Science Research - SomaLogic

BlogPlasma proteins reveal molecular signatures of aging and frailty. Plasma proteins reveal molecular signatures of aging and frailty. Learn more. BlogWhy ...

Plasma proteomic profile of frailty - Aging Cell - Wiley Online Library

Pathway analysis with the top 143 frailty-associated proteins revealed enrichment for proteins in pathways related to lipid metabolism ...

Proteomic aging clock predicts mortality and risk of common ... - Nature

Circulating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction ...

Markers of aging: Unsupervised integrated analyses of the human ...

Molecular signatures of such age-associated changes have been found ... plasma signature is more strongly associated with aging compared to other proteins.

Late‐life plasma proteins associated with prevalent and incident ...

Aging Cell is an open access geroscience journal addressing the biology of aging, from molecular mechanisms of aging to age-related disease.

The intersection of frailty and metabolism - Cell Press

However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging ...

Associations of plasma proteomics and age-related outcomes with ...

Organ aging signatures in the plasma proteome track health and disease ... Biology of individual proteins. A The majority of BAG-associated ...

Age prediction from human blood plasma using proteomic and small ...

Our study measured two types of molecular data (proteins and ... Protein profiling reveals consequences of lifestyle choices on predicted biological aging.

Aging and putative frailty biomarkers are altered by spaceflight

Human space exploration poses inherent risks to astronauts' health, leading to molecular changes that can significantly impact their ...

Multi-modal profiling of peripheral blood cells across the human ...

Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity.

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific ...

Gene expression signatures reflect molecular mechanisms of mammalian aging, maximum lifespan, and mortality. A. Overview of samples from the ...

Exploring molecular signatures related to the mechanism of aging in ...

Hub genes of each brain region were determined by protein–protein interaction network analysis, and commonly expressed DEGs (co-DEGs) were also ...

Single nuclei profiling identifies cell specific markers of skeletal ...

This combined approach revealed changes in gene expression that occur with age and frailty in multiple cell types comprising mature skeletal muscle.

Biomarkers of aging in frailty and age-associated disorders

Inflammaging markers characteristic of advanced age show similar levels with frailty ... Plasma protein biomarkers of the geriatric syndrome of frailty. J.

Plasma proteomic biomarker signature of age predicts health ... - eLife

We show that individual age-related proteins are predictive of both ... molecular mechanisms of age-associated differences in protein expression.