Plasminogen activation independent of uPA and tPA maintains ...

Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), results in a substantial delay in ...

Plasminogen activation independent of uPA and tPA ... - PubMed

Plasminogen activation independent of uPA and tPA maintains wound healing in gene- ... EMBO J. 2006 Jun 21;25(12):2686-97. doi: 10.1038/sj.emboj.7601173.

Plasminogen activation independent of uPA and tPA ... - EMBO Press

Plasminogen activation independent of uPA and tPA maintains wound healing in gene‐deficient mice ... Simultaneous ablation of the two known activators of ...

Plasminogen activation independent of uPA and tPA maintains ...

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. ... Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, ...

uPA-mediated plasminogen activation is enhanced by polyphosphate

Efficient tPA-mediated plasminogen activation requires binding to fibrin. In contrast, uPA is fibrin independent and activates plasminogen in ...

Therapeutics targeting the fibrinolytic system - Nature

Plasmin is activated via the cleavage of the inactive zymogen plasminogen (Plg) by plasminogen activators (tPA/uPA) or other enzymes, e.g., ...

Diversity and functional evolution of the plasminogen activator system

The serine protease domain of uPA has high affinity for its substrate which generate activated protease plasmin by cleaving inactive zymogen plasminogen [Fig. 1] ...

Plasminogen activation independent of uPA and tPA maintains ...

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice ... Authors: Leif R Lund; Kirsty A Green; Allart A Stoop; Michael ...

Plasminogen activator receptor assemblies in cell signaling, innate ...

Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are serine proteases and major activators of fibrinolysis in ...

Antibody-mediated Targeting of the Urokinase-type Plasminogen ...

Urokinase-type plasminogen activator (uPA) plays a central role in tissue remodeling processes. Most of our understanding of the role of uPA in vivo is ...

Role of Plasminogen Activation System in Platelet Pathophysiology

Plasminogen activators, uPA and tPA, can be provided by platelets, and in turn, they bind the platelet surface through specific receptors. While ...

Enhanced Expression of Plasminogen Activators and Inhibitor in the ...

Our study found that plasminogen activation (uPA, uPAR, tPA) ... activation independent of uPA and tPA maintains wound healing in gene-deficient ...

Contrasting Effects of Plasminogen Activators, Urokinase Receptor ...

We propose four possible mechanisms whereby UPAR may modulate SMC migration and invasion. First, UPA may bind to UPAR, activate cell-associated ...

Fibrinolytic therapy with tPA failed because it was based on a flawed ...

Instead, tPA 's function is limited to the initiation of fibrinolysis, which is continued by urokinase plasminogen activator (uPA) and that has the dominant ...

Plasminogen activation independent of uPA and tPA maintains ...

Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), ...

Plasminogen activation independent of uPA and tPA maintains ...

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice · Abstract · Adgang til dokumentet · Citationsformater.

Mice Lacking tPA, uPA, or Plasminogen Genes Showed Delayed ...

... activation of these growth factors may be necessary to stimulate and maintain nerve regeneration. ... Both tPA and uPA, independent of plasminogen, activate the.

Tranexamic acid for haemostasis and beyond: does dose matter?

While both uPA and tPA cleave plasminogen at the same site to generate active plasmin, there are important features that separate tPA and uPA.

New insights into the molecular mechanisms of the fibrinolytic system

Mechanisms of tissue- type plasminogen activator (tPA) clearance by the liver. ... Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-. uPA) ...

Dysregulated fibrinolysis and plasmin activation promote the ...

We showed that uPA and uPAR produced inflammatory and degradative mediators by activating the PI3K, 3′-phosphoinositide-dependent kinase-1, AKT, ...