Platelet|derived growth factor receptor

Platelet-derived growth factor receptor - Wikipedia

PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including ...

Platelet-derived growth factors and their receptors: structural and ...

The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF receptors (PDGFRs, which belong to class III receptor tyrosine kinases) ...

Platelet Derived Growth Factor - an overview | ScienceDirect Topics

Platelet-derived growth factor (PDGF) consists of 4 subtypes that dimerize to activate 2 structurally related cell surface tyrosine kinase receptors,42 causing ...

Structural and Functional Properties of Platelet-Derived Growth ...

The receptors for platelet-derived growth factor (PDGF) and stem cell factor (SCF) are members of the type III class of PTK receptors, ...

Platelet-Derived Growth Factor - an overview | ScienceDirect Topics

Platelet derived growth factor (PDGF) is composed of dimers of A and/or B chains and acts via two tyrosine kinase receptors PDGFR-α and -β. Early in gestation, ...

Mechanism of Action and In Vivo Role of Platelet-Derived Growth ...

Platelet-derived growth factor isoforms exert their effects on target cells by activating two structurally related protein tyrosine kinase receptors. The α- and ...

Platelet-derived growth factor - Wikipedia

In both mouse and human, the PDGF signalling network consists of five ligands, PDGF-AA through -DD (including -AB), and two receptors, PDGFRalpha and PDGFRbeta.

PDGFRA gene: MedlinePlus Genetics

The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a ...

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR ...

In this review, we summarize data regarding the mechanisms and significance of PDGF/PDGFR expression in normal conditions and tumors, focusing on this axis as ...

PDGFRA - Platelet-derived growth factor receptor alpha | UniProtKB

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic ...

Definition of platelet-derived growth factor receptor alpha gene

NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.

PDGF Protein | Platelet-derived growth factor - Prospec Bio

Known as the receptor for PDGF, PDGFR is known as a receptor tyrosine kinase or RTK, which is a type of cell surface receptor. There are two types of PDGFRs ...

Platelet-derived Growth Factor (PDGF) Signaling Pathway

The PDGFs bind to the protein tyrosine kinase receptors PDGFRA and PDGFRB. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three ...

PDGFRB gene: MedlinePlus Genetics

The PDGFRB gene provides instructions for making a protein called platelet-derived growth factor receptor beta (PDGFRβ), which is part of a family of proteins ...

3MJG: The structure of a platelet derived growth factor receptor ...

A large-scale structural organization and rearrangement is observed for PDGF-B upon receptor binding, in which the PDGF-B L1 loop, disordered in ...

platelet derived growth factor receptor alpha | Type III RTKs

The IUPHAR/BPS Guide to Pharmacology. platelet derived growth factor receptor alpha - Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family.

RETRACTED ARTICLE: Platelet-derived growth factor receptor-α and

These results indicate that PDGFR-α/β activity is upregulated in sarcoma CSCs and promote CSC phenotypes including migration, invasion, and ...

What is Platelet-Derived Growth Factor and Its Receptor?

PDGF is a serum growth factor, mainly synthesized by megakaryocytes, stored in platelets, and released into the blood by external stimuli.

Involvement of platelet‐derived growth factor ligands and receptors ...

PDGF stimulates cells in tumour stroma and promotes angiogenesis as well as the development of cancer-associated fibroblasts, both of which promote tumour ...

Overexpression of platelet-derived growth factor receptor α in breast ...

Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and progression of ...