Pleiotropy and Cross|Disorder Genetics Among Psychiatric Disorders

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

Genome-wide analyses of common and rare genetic variations have documented the heritability of major psychiatric disorders, ...

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

In this review, we summarize evidence in psychiatry for pleiotropy at multiple levels of analysis: from overall genome-wide correlation to biological pathways.

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

In recent years, these studies have illuminated another key feature of the genetic basis of psychiatric disorders: the important role and ...

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

Pleiotropy and Cross-Disorder Genetics Among. Psychiatric Disorders. Phil H. Lee, Yen-Chen A. Feng, and Jordan W. Smoller. ABSTRACT. Genome-wide analyses of ...

Genomic Relationships, Novel Loci, and Pleiotropic ... - Cell Press

Fourth, we found extensive evidence that neurodevelopmen- tal effects underlie the cross-disorder genetics of mental illness. In addition to DCC ...

Identification of pleiotropy at the gene level between psychiatric ...

This study demonstrates that mental disorders and related traits do show pleiotropy at the gene level as well as the single-marker level. The ...

Multiple Common Genetic Loci Underlie Eight Psychiatric Disorders

These pleiotropic loci were distinguishable from disorder-specific loci by their involvement in pathways such as neurogenesis, regulation of ...

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

Genome-wide analyses of common and rare genetic variations have documented the heritability of major psychiatric disorders, established their highly ...

Leveraging pleiotropy for the improved treatment of psychiatric ...

1A) [11, 12]. Large positive genetic correlations are also frequently observed between pairs of psychiatric disorders [7]. One explanation ...

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

Semantic Scholar extracted view of "Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders" by Phil H. Lee et al.

Shared genetic architecture across psychiatric disorders

This indicates that cross-disorder genomic efforts in the near future should look beyond solely identifying additional pleiotropic loci as this ...

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders

In recent years, these studies have illuminated another key feature of the genetic basis of psychiatric disorders: the important role and pervasive nature of ...

Brain functional connectivity mirrors genetic pleiotropy in psychiatric ...

Pleiotropy occurs when a genetic variant influences more than one trait. This is a key property of the genomic architecture of psychiatric disorders and has ...

The implications of the shared genetics of psychiatric disorders

Pleiotropy in psychiatry and developmental disorders. Evidence for cross-disorder effects of genetic variation has come from stud- ies ...

Cross-Trait Meta-Analysis Explores Potential Pleiotropy Across ...

Researchers considered genetic overlap between pairs of psychiatric conditions and across 12 psychiatric disorders, ...

Cross-Disorder Working Group, of the Psychiatric Genomics ...

Psychiatric genetics, cross-disorder genetics, psychiatric disorders, pleiotropy, neurodevelopment, GWAS, genetic correlation, gene expression. Page 4. 3.

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms ...

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci.

Cross Disorder Analyses Working Group – PGC

Analyses led by the Cross-Disorder group have identified pleiotropic effects and genetic ... Genetic relationship between five psychiatric disorders estimated ...

Genome wide meta-analysis identifies genomic relationships, novel ...

The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning in the second ...

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms ...

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, ...