Pluripotent stem cell energy metabolism

Energy Metabolism Regulates Stem Cell Pluripotency - Frontiers

This review highlights the roles of the major metabolic pathways in the acquisition and maintenance of the different states of pluripotency.

Pluripotent stem cell energy metabolism: an update - PMC - NCBI

Factors that activate glycolysis and inhibit OXPHOS promote induced PSC (iPSC) reprogramming. Vitamin C enhances iPSC reprogramming as an antioxidant and as a ...

Energy Metabolism Regulates Stem Cell Pluripotency - PMC

This review highlights the roles of the major metabolic pathways in the acquisition and maintenance of the different states of pluripotency.

Metabolism of human pluripotent stem cells and differentiated cells ...

Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling.

Metabolic regulation in pluripotent stem cells - ScienceDirect.com

PSCs reshape their metabolic profile during developmental progression. Fatty acid oxidation is strictly required for energy production in naive PSCs.

Measuring energy metabolism in cultured cells, including human ...

In human pluripotent stem cells (hPSCs) and their differentiated progeny, this analysis can be challenging because of the unique cell properties ...

Energy Metabolism in Human Pluripotent Stem and Differentiated ...

Evaluating cell metabolism is crucial during pluripotent stem cell (PSC) differentiation and somatic cell reprogramming as it affects cell fate.

Regulation of energy metabolism in human pluripotent stem cells

In this review, we will discuss key factors that influence energy metabolism and their association with stem cell functions.

A roadmap for the characterization of energy metabolism in human ...

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are an increasingly employed model in cardiac research and drug discovery. As cellular ...

Energy Metabolism in Human Pluripotent Stem Cells and ... - PLOS

ATP levels, lactate production and OCR revealed that human pluripotent cells rely mostly on glycolysis to meet their energy demands.

OCIAD1 Controls Electron Transport Chain Complex I Activity to ...

Pluripotent stem cells (PSCs) derive energy predominantly from glycolysis and not the energy-efficient oxidative phosphorylation (OXPHOS).

Energy Metabolism Plays a Critical Role in Stem Cell Maintenance ...

Various stem cells gradually turned to be critical players in tissue engineering and regenerative medicine therapies. Current evidence has demonstrated that ...

Pluripotent stem cell energy metabolism: an update - eScholarship

Recent studies link changes in energy metabolism with the fate of pluripotent stem cells (PSCs). Safe use of PSC derivatives in regenerative medicine ...

Energy Metabolism Regulates Stem Cell Pluripotency - Mayo Clinic

Abstract. Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited self-renewal and their potential to ...

Metabolism in Pluripotent Stem Cells and Early Mammalian ...

In general, PSCs exhibit a high glycolytic flux to support high energy and biosynthetic demands during rapid proliferation. (Folmes et al., 2011 ...

Pluripotent stem cell energy metabolism: an update. – CIRM

Recent studies link changes in energy metabolism with the fate of pluripotent stem cells (PSCs). Safe use of PSC derivatives in regenerative medicine ...

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human ...

As an example, glycolysis is a major energy source for immature CMs. As CMs mature, the mitochondrial oxidative capacity increases, with fatty ...

Regulation of energy metabolism in human pluripotent stem cells

Energy production is not only essential for cell survival and proliferation, but also critical for pluripotency and cell fate determination. Thus, energy ...

Energy Metabolism Regulates Stem Cell Pluripotency

Understanding of the role of metabolism in PSC fate has expanded from anabolism and catabolism to include governance of the pluripotent ...

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu.