Polygenic Multiple Sclerosis Risk and Population‐Based Childhood ...

We found evidence for a relationship between the combination of common genetic variants for MS and brain imaging phenotypes. Namely, we found a positive ...

Polygenic Multiple Sclerosis Risk and Population-Based Childhood ...

This is the first study to show that greater genetic predisposition for MS is associated with higher global brain WM FA at an early age in the general ...

Whether genetic risk for MS is associated with brain structure during early neurodevelopment remains unclear. In this study, we explore the ...

Polygenic Multiple Sclerosis Risk and Population‐Based Childhood ...

Polygenic Multiple Sclerosis Risk and Population-Based Childhood. Brain Imaging. C. Louk de Mol, BSc ,1,2 Philip R. Jansen, MD, PhD,1,3,4,5,6 Ryan L. Muetzel ...

Polygenic Multiple Sclerosis Risk and Population-Based Childhood ...

Polygenic Multiple Sclerosis Risk and Population-Based Childhood. Brain Imaging. C. Louk de Mol, BSc ,1,2 Philip R. Jansen, MD, PhD,1,3,4,5,6 ...

Polygenic susceptibility for multiple sclerosis is associated with ...

In the current study, we identified a significant correlation between higher polygenic risk for MS, based on the largest GWAS to date, and lower ...

Genetic Risk for MS Linked to White Matter Changes in Brains of...

Depending on how significantly variants were associated with MS, researchers calculated eight different polygenic scores for each child. The ...

Polygenic susceptibility for multiple sclerosis is associated with ...

Methods We generated a polygenic risk score (PRS) of MS and investigated its association with WM performance in a population of 3282 healthy ...

Predicting Multiple Sclerosis: Challenges and Opportunities - Frontiers

Polygenic multiple sclerosis risk and population-based childhood brain imaging. ... children and genetic risk for multiple sclerosis: a population-based study.

White matter microstructural differences in children and genetic risk ...

Genetic risk for MS is associated with spatially distinct clusters of increased FA during childhood brain development. Introduction. Multiple ...

Elevated genetic risk for multiple sclerosis emerged in steppe ...

Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe.

(PDF) T cell composition and polygenic multiple sclerosis risk

We observed no significant associations for the T cell specific PRSs. Conclusion Our results suggest that MS-associated genetic variants affect ...

Genetics of multiple sclerosis: lessons from polygenicity - The Lancet

Large-scale mapping studies have identified 236 independent genetic variants associated with an increased risk of multiple sclerosis.

No evidence for association between polygenic risk of multiple ...

These PRS explained 1.5% (MHC) and 1.3% (non-MHC) of MS susceptibility (Nagelkerke's pseudo-R2 on the observed scale). As would be expected, ...

(PDF) Multiple Sclerosis Polygenic Risk Is Not Enriched in Three ...

The wPRS of familial MS cases was not significantly different to population-based MS cases (P>0.05). Both affected and unaffected MS family ...

Gene-Environment Interactions in Multiple Sclerosis - Neurology.org

There was strong evidence of interaction between polygenic risk for MS and childhood obesity (PRSMHC: AP = 0.17, 95% CI 0.06–0.25, p = 0.004; PRSnon-MHC: AP = ...

Multiple sclerosis risk variants influence the peripheral B‐cell ...

Recently, we have shown that children from a population- based study with a high polygenic risk for MS show alterations in the white matter ...

Predicting Multiple Sclerosis: Challenges and Opportunities - Frontiers

... polygenic risk score, Multiple Sclerosis, genetics, environmental risk ... Polygenic multiple sclerosis risk and population-based childhood brain.

Integration of epigenetic and genetic profiles identifies multiple ...

Cell-specific polygenic risk scores were developed to examine the cumulative impact of the susceptibility genes on MS risk and clinical ...

T cell composition and polygenic multiple sclerosis risk

Multiple sclerosis (MS)‐associated genetic variants affect T cell composition during childhood (n = 675). Higher MS polygenic risk was associated with lower ...