Polygenic predisposition to hypertension predicts blood ...

Polygenic Risk Scores Predict Hypertension Onset and ... - PubMed

We demonstrate that genetic information improves hypertension risk prediction. BP PRSs together with traditional risk factors could improve prediction of ...

Polygenic predisposition to hypertension predicts blood pressure ...

There has been a lot of research about polygenic risk for, let's say, hypertension and the clinical outcomes. So we know that polygenic ...

Polygenic Risk Scores Predict Hypertension Onset and ...

Systolic and diastolic blood pressure polygenic risk scores improved clinical risk prediction of hypertension, increasing the C statistics by ...

Polygenic Susceptibility to Hypertension and Blood Pressure ...

Blood pressure (BP) is often not at goal in stroke survivors, leaving individuals vulnerable to additional vascular events.

Polygenic Resistance to Blood Pressure Treatment and Stroke Risk ...

Common genetic variation explains up to 40% of inter-individual BP variability. Despite this compelling physiological impact, its role in BP ...

Polygenic predisposition to hypertension predicts blood ... - YouTube

Shufan Huo, MD, PhD, Yale School of Medicine, New Haven, CT, explains her work studying the impact of polygenic predisposition to ...

Dissecting the Polygenic Basis of Primary Hypertension - Frontiers

Introduction and Objectives: Genome-wide association studies have identified a high number of genetic loci associated with hypertension ...

Polygenic risk scores associate with blood pressure traits across the ...

Recent studies indicate that genome-wide PRSs for BP traits can improve clinical risk prediction of hypertension in adults.17,18 Moreover, the contrasting BP ...

Integration of polygenic risk score with non-genetic determinants

Meanwhile, an individual's BP is also determined to some extent by genetic predisposition. In fact, numerous BP-related genes have been ...

BP Polygenic Risk Scores May Complement Measured BP for CVD ...

In a large cohort of U.K. women, genetic predisposition to high blood pressure and higher body mass index was significantly associated with ...

Polygenic Interactions With Environmental Exposures in Blood ...

What Are the Clinical Implications? ... Several modifiable risk factors for hypertension may have differential effects on phenotypic expression ...

Genetic predisposition to high blood pressure and out-of-office ...

Unlike family history, polygenic risk scores provide incremental information identifying individuals with ambulatory hypertension. However, ...

Genome-wide analysis in over 1 million individuals of European ...

Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% ...

polygenic risk scores predict hypertension onset and cardiovascular ...

We demonstrated that genetic information improves clinical risk prediction of hypertension. Blood pressure PRSs could be used together with traditional risk ...

Study finds 500 new blood pressure genes - VUMC News

The findings, published April 30 in the journal Nature Genetics, include improved polygenic scores for predicting blood pressure and the discovery of 500 ...

Study uncovers the role of polygenic risk scores in hypertension ...

The genetic predisposition to hypertension was quantified using a previously validated systolic blood pressure polygenic risk score. The ...

Genetic Predisposition to High Blood Pressure and Out-of-Office ...

The BP polygenic risk score (PRS) is a function of the GWAS SNP-phenotype effect estimate as well as the genotype of a given individual at that ...

Hypertension: How genes may help predict high blood pressure risk

By using polygenic risk scores, scientists said they found that study participants with the highest genetic risk for hypertension have mean ...

What a Polygenic Risk Score Can and Can't Tell You

As a cardiologist, Pradeep Natarajan, MMSc '15, knows that high blood pressure, smoking, and high cholesterol raise a patient's risk of ...

Measured Blood Pressure, Genetically Predicted ... - JAMA Network

Meaning Blood pressure polygenic risk scores may complement measured blood pressure to achieve earlier and targeted cardiovascular disease ...