Positive and negative durotaxis

Positive and negative durotaxis - mechanisms and emerging concepts

Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal dynamics, contractility and cell extrinsic cues.

Positive and negative durotaxis – mechanisms and emerging concepts

Types of durotaxis. On stiffness gradients, single cells can exhibit either positive durotaxis (. View largeDownload slide. Types of durotaxis.

Durotaxis and negative durotaxis: where should cells go? - Nature

Durotaxis is the tendency of cells to migrate toward stiffer areas, while negative durotaxis occurs when cells migrate toward regions with lower stiffness.

Positive, negative and controlled durotaxis - RSC Publishing

We show that positive and negative durotaxis found across cell types are explained by asymmetries in the cell adhesion dynamics.

Directed cell migration towards softer environments - PubMed

In agreement with this model, negative durotaxis is selectively disrupted and even reversed by the partial inhibition of actomyosin contractility. Conversely, ...

Positive, negative and controlled durotaxis - NASA/ADS

Even so, certain cells follow positive stiffness gradients while others move along negative gradients. How the physical mechanisms involved in cell migration ...

Positive, negative and engineered durotaxis - bioRxiv

We show that positive and negative durotaxis found across cell types are explained by asymmetries in the cell adhesion dynamics.

(PDF) Positive, negative and controlled durotaxis - ResearchGate

Specifically, the ability of cells to follow stiffness gradients, known as durotaxis, is ubiquitous across most cell types. Even so, certain cells follow ...

Volume 137 Issue 8 | Journal of Cell Science

Positive and negative durotaxis – mechanisms and emerging concepts · Mathilde Mathieu,Aleksi Isomursu,Johanna Ivaska. Summary: A discussion of how increasing ...

Positive and negative durotaxis – mechanisms and emerging ...

Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal dynamics, contractility and cell extrinsic cues.

An elastic-damaging cohesive law for cell-substrate adhesion with ...

... positive and negative durotaxis ... The table collects a series of figures illustrating the reversal of positive durotaxis into negative durotaxis ...

Durotaxis: Current Biology - Cell Press

Such negative durotaxis occurs during the development of the Xenopus optic pathway, when retinal ganglion cell axons grow towards softer tissue.

Positive, negative and controlled durotaxis. - Semantic Scholar

It is shown how durotaxis can be engineered to manipulate cell migration, which has important implications in biology, medicine, and bioengineering.

Negative durotaxis: cell movement toward softer environments

Durotaxis – the ability of cells to sense and migrate along stiffness gradients – is important for embryonic development and has been implicated ...

Positive and negative durotaxis - mechanisms and emerging concepts.

Significant conceptual advances that have been made in the appreciation of cell plasticity and context dependency in stiffness-guided directional cell ...

YAP Activation in Promoting Negative Durotaxis and Acral ... - MDPI

Directed cell migration towards a softer environment is called negative durotaxis. The mechanism and pathological relevance of negative durotaxis in tumor ...

An Elastic-Damaging Cohesive Law for Cell-Substrate Adhesion ...

Finite elasticity of the cell body is considered while durotaxis is triggered by applying a contractile pre-stretch to the cell. It is shown ...

Magazine

These results suggest that different modes of durotaxis (positive and negative) may operate via different pathways. The search for molecular ...

Stopping Cancer Cells' Movement and Changing Their Direction

This 'negative durotaxis' does not coincide with changes in canonical mechanosensitive signaling or actomyosin contractility. Instead, as ...

Directed cell migration towards softer environments

Conversely, positive durotaxis can be switched to negative by lowering the optimal stiffness by the downregulation of talin—a key clutch compo- nent. Our ...