Positive feedback loop PU.1|IL9 in Th9 promotes rheumatoid ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid ...

We uncovered that PU.1 and IL-9 form a positive feedback loop in RA: (1) PU.1 directly binds to the IL-9 promoter, activating its transcription and (2) Th9- ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid ...

These results support that the PU.1-IL-9 axis forms a positive loop in Th9 dysregulation of RA. Targeting this signalling axis presents a ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid ...

The pathogenesis of rheumatoid arthritis (RA) is complex and existing drugs have many shortcomings, including low response rates, adverse reactions, ...

(PDF) Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid ...

PDF | Objectives T helper 9 (Th9) cells are recognised for their characteristic expression of the transcription factor PU.1 and production ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid ... - OUCI

ObjectivesT helper 9 (Th9) cells are recognised for their characteristic expression of the transcription factor PU.1 and production of interleukin-9 (IL-9), ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid ...

The pathogenesis of rheumatoid arthritis (RA) is complex and existing drugs have many shortcomings, including low response rates, ...

Annals of the Rheumatic Diseases on X: "Positive feedback loop PU ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development Study in PU.1-T cell-conditional knockout (KO) mice, IL-9 ...

The PU.1– IL-9 axis in TH9 cells promotes RA - ResearchGate

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development. August 2024 · Annals of the Rheumatic Diseases.

Research highlights - Nature

Collectively, these data show a positive feedback loop between. IL-9 and ... loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development. Ann Rheum ...

The PU.1– IL-9 axis in TH9 cells promotes RA - OUCI

List of references. Tu, J. et al. Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development. Ann Rheum Dis https://doi.org/10.1136/ard ...

Annals of the Rheumatic Diseases on X: "What is the link between ...

... PU.1 transcription factor and IL-9 in #rheumatoid arthritis? PU.1 promote Th9 differentiation in a positive feedback loop: ▶PU.1 activates IL- ...

Potential involvement of IL-9 and Th9 cells in the pathogenesis of ...

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development. · Medicine. Annals of the rheumatic diseases · 2024.

Interleukin-9 and T helper type 9 cells in rheumatic diseases

Th9 cells develop from naive T cells in the presence of transforming growth factor (TGF)-β, IL-4 and thymic stromal lymphopoietin (TSLP) (Fig. 1) and require PU ...

Induction of IL-9 in Peripheral Lymphocytes of Rheumatoid Arthritis ...

... RA and HD regardless of Th9- or Th17-promoting cytokine milieus. Whereas ... Keywords: Th9, Th17, interleukin-9, rheumatoid arthritis, PU.1. Citation ...

Regulatory role of T helper 9/interleukin-9: Transplantation view

TGF-β promotes Th9 differentiation by inhibiting T-bet (a Th1-specific transcription factor) and inducing PU.1 [25,50]. Similar to that of Th2 ...

Regulatory role of T helper 9/interleukin-9: Transplantation view

Recent research has shown that the differentiation of Th9 cells is coregulated by the transcription factors transforming growth factor β (TGF-β), IL-4, and PU.1 ...

Synovial IL-9 facilitates neutrophil survival, function and ...

We demonstrated synovial enrichment of Th9 cells and their positive correlation with disease activity (DAS28-ESR) in RA. Synovial IL-9 prolonged ...

STAT6-Dependent Regulation of Th9 Development - AAI Journals

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development. Jiajie Tu, Weile Chen, Wei Huang, et al., Ann Rheum Dis, 2024. P02.04 Tissue ...

Features and roles of T helper 9 cells and interleukin 9 in ... - Elsevier

... PU.1 to promote TH9 development.72. STAT6, GATA3 and IRF4. TH9 ... Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis.

PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental ...

Furthermore, chronic inflammation in patients with inflammatory bowel diseases [IBD: Crohn´s disease, ulcerative colitis]5–7 may cause the development of ...