Potential role of platelet|derived growth factor receptor inhibition ...

Potential Role of Platelet-Derived Growth Factor Receptor Inhibition ...

Introduction: Platelet-derived growth factor receptor (PDGFR) is expressed in lung cancer and is involved in angiogenesis. Preclinical models demonstrated that ...

Insights Into the Role of Platelet-Derived Growth Factors

Platelet-derived growth factor regulates the functional activities of neurons by regenerating, stabilizing, and stimulating the synapses of neuronal axons, ...

Inhibition of Platelet-Derived Growth Factor Receptor Signaling ...

PDGF-induced activation of cytoplasmic cAbl plays an important role in mediating actin assembly and regulation of cell shape [13]. In neurons, inhibition of ...

Platelet-Derived Growth Factor Receptor Inhibition ... - AACR Journals

Purpose: To further assess preclinical and early clinical evidence that imatinib mesylate, a platelet-derived growth factor receptor (PDGFR) ...

Platelet-Derived Growth Factor Receptor - ScienceDirect.com

These receptors play a crucial role in regulating the migration and generation of oligodendrocyte progenitor cells in the brain, as well as in tumor ...

Use of multitarget tyrosine kinase inhibitors to attenuate platelet ...

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) play a fundamental role in the embryonic development of the lung.

New natural compound inhibitors of PDGFRA (platelet-derived ...

Objective: The purpose of this study was to screen lead compounds and candidate drugs with potential inhibitors against platelet-derived growth factor receptor ...

Involvement of platelet‐derived growth factor ligands and receptors ...

PDGF receptor kinase inhibitors have been shown to ameliorate the symptoms in the bleomycin and tight skin 1 experimental mouse models 92-94 and ...

Mechanism of Action and In Vivo Role of Platelet-Derived Growth ...

Platelet-derived growth factor isoforms exert their effects on target cells by activating two structurally related protein tyrosine kinase receptors. The α- and ...

The platelet-derived growth factor receptor as a therapeutic target

Increasing evidence indicates that inhibition of other tumor stromal targets could provide additional and possibly synergistic antitumor effects ...

Inhibition of the platelet-derived growth factor receptor beta ...

PDGFRB-silencing caused a decrease in the proliferation rate, and a reduced colony formation capacity, as well as an increase of the share of ...

CP-673451, a Selective Platelet-Derived Growth Factor Receptor ...

Further exploration of their roles may provide valuable insights into potential treatment strategies for CCA. PDGFR inhibitors, such as imatinib and ...

Targeting the PDGF signaling pathway in tumor treatment

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of ...

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR ...

PDGF and their receptors were identified in a large variety of human tumor cells. In experimental models it was shown that inhibition of PDGF reduces ...

Identification of potential bioactive phytochemicals for the inhibition ...

Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders ...

RETRACTED ARTICLE: Platelet-derived growth factor receptor-α and

Platelet-derived growth factor receptors α and β (PDGFR-α/β) play an important role in the maintenance of mesenchymal stem cells. Here we ...

Antagonism of Platelet-Derived Growth Factor Receptor in Non ...

Given its progrowth role in cell signaling, PDGFR has been an attractive therapeutic target in a number of human malignancies. Imatinib mesylate ...

Role of platelet-derived growth factors in physiology and medicine

tional PDGF ligand or receptor retaining the ability to dimerize is a potential ... Inhibition of platelet-de- rived growth factor receptor phosphorylation by ...

EMERGING ROLES OF PLATELET-DERIVED GROWTH FACTOR ...

Platelet-derived growth factor receptor (PDGFR) is a tyrosine kinase receptor that plays a role in cell survival, proliferation, and ...

Platelet-derived Growth Factor Induces a Long-term Inhibition of N ...

Non-NMDA receptor function was not affected by PDGF in hippocampal neurons. Experiments with mutant PDGFRs and chelation of intracellular Ca2+ in Xenopus ...