Practical Issues in Imputation|Based Association Mapping

Practical Issues in Imputation-Based Association Mapping - PLOS

We find that imputation-based methods can be robust to imputation accuracy and can improve power to detect associations, even when average imputation accuracy ...

Practical Issues in Imputation-Based Association Mapping - PMC

The basic idea is to exploit the fact that, due to correlation among untyped and typed SNPs, genotypes of untyped SNPs in each study can be ...

Practical Issues in Imputation-Based Association Mapping - PLOS

Larger increases in imputation error rate, obtained when using YRI panel that is not well-matched to sample, produce a notable reduction in performance (right; ...

Practical Issues in Imputation-Based Association Mapping

It is found that imputation-based methods can be robust to imputation accuracy and can improve power to detect associations, even when average imputations ...

Practical aspects of imputation-driven meta-analysis of genome ...

Abstract. Motivated by the overwhelming success of genome-wide association studies, droves of researchers are working vigorously to exchange ...

The hazards of genotype imputation when mapping disease ...

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661–678. Howie BN ...

Evaluation of imputation-based association in and around the ...

... IMputation Based Association Mapping' method implemented in BIMBAM (11). ... M. Practical issues in imputation-based association mapping. ,. PLoS Genet ...

Association Mapping in Structured Populations - ScienceDirect.com

Despite the success and popularity of family-based methods such as the TDT, the problem of how to perform valid case-control association studies is of ...

The Relationship between Imputation Error and Statistical Power in ...

Guan, Y. ∙ Stephens, M. Practical issues in imputation-based association mapping. PLoS Genet. 2008; 4:e1000279. Crossref.

Practical aspects of imputation-driven meta-analysis of genome ...

Practical aspects of imputation-driven meta-analysis of genome-wide association studies. ... association mapping. Expand. 2,693 Citations · Highly Influential.

The Relationship between Imputation Error and Statistical Power in ...

Practical issues in imputation-based association mapping. PLoS Genet., 4 ... Practical aspects of imputation-driven meta-analysis of genome-wide association ...

Practical aspects of imputation-driven meta-analysis of genome ...

Motivated by the overwhelming success of genome-wide association studies, droves of researchers are working vigorously to exchange and to combine genetic data ...

Association Mapping and Disease: Evolutionary Perspectives

Guan Y, Stephens M (2008) Practical issues in imputation-based association mapping. PLoS Genet 4:e1000279. https://doi.org/10.1371/journal ...

Practical Issues in Imputation-Based Association Mapping - CORE

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Imputation-Based Analysis of Association Studies: Candidate ...

In practice, typical analyses involve testing each typed SNP individually, and in some cases combinations of typed SNPs jointly (e.g.,.

Genome-wide association studies | Nature Reviews Methods Primers

A basic principle of successful fine-mapping is to expand the coverage of the genetic variants assessed by using, for example, WGS-based ...

The Relationship between Imputation Error and Statistical Power in ...

of the genome that is suited to imputation-based associa- tion mapping. ... Practical issues in imputa- tion-based association mapping. PLoS Genet. 4 ...

Error rates (proportion of cases where the most probable genotype ...

from publication: Practical Issues in Imputation-Based Association Mapping | Imputation-based association methods provide a powerful framework for testing ...

CIDR Health Retirement Study Imputation Report - 1000 Genomes ...

Practical aspects of imputation-driven meta-analysis of genome-wide ... Practical issues in imputation-based association mapping. PLoS Genet ...

An empirical evaluation of imputation accuracy for association ...

... map. Based on the well known ... de Bakker PI: Practical aspects of imputation-driven meta-analysis of genome-wide association studies.