Preclinical and Clinical Development of Noncoding RNA ...

In this review, we focus on noncoding RNA-based studies conducted mainly in large-animal models, including pigs, rabbits, dogs, and nonhuman primates.

Preclinical and Clinical Development of Noncoding RNA ... - PubMed

RNA modulation has become a promising therapeutic approach for the treatment of several types of disease. The emerging field of noncoding ...

preclinical and clinical development of small non-coding RNA ...

Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in size and function able to inhibit gene expression ...

preclinical and clinical development of small non-coding RNA ...

In this review we report the biology of miRNAs and siRNAs in relation to cancer summarizing the recent methods described to use them as novel therapeutic drugs.

Noncoding RNA therapeutics — challenges and potential solutions

& Calin, G. A. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. ... In vitro antiviral activity and preclinical and ...

Preclinical and Clinical Development of Noncoding RNA ...

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease · Cheng-Kai Huang, S. Kafert-Kasting, T. Thum · Published in ...

Preclinical and Clinical Development of Noncoding RNA ...

REVIEW. Preclinical and Clinical Development of. Noncoding RNA Therapeutics for Cardiovascular. Disease. Cheng-Kai Huang, ...

Preclinical and clinical development of siRNA-based therapeutics

Knowledge of the multiple actions of non-coding RNAs has truly allowed viewing DNA, RNA and proteins in novel ways. Small interfering RNAs (siRNAs) can be used ...

A systematic review of non-coding RNA therapeutics in early clinical ...

Ongoing and completed phase 1, 2 or 3 trials were included. Exclusion criteria were preclinical trials only, non-English reports, no RNA ...

Preclinical and Clinical Development of Noncoding RNA ...

RNA modulation has become a promising therapeutic approach for the treatment of several types of disease. The emerging field of noncoding RNA-based ...

Preclinical and Clinical Development of Noncoding RNA ... - OUCI

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease ... noncoding RNA-based drugs in clinical trials. Additional ...

RNA-based therapeutics: an overview and prospectus - Nature

Preclinical research on IVT mRNA promotes the clinical development of mRNA-based vaccination against cancer and infectious disease [7].

Advancements in clinical RNA therapeutics: Present developments ...

through preclinical and clinical development, underscoring the viability of harnessing RNA as a standalone medicinal entity. This section ...

(PDF) Novel approaches in cancer treatment: preclinical and clinical ...

PDF | Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in size and function able to inhibit gene expression based on.

Noncoding RNA therapeutics for substance use disorder

While there have been no clinical trials using miR-targeting therapeutics in SUD patients, several miRs have been explored functionally in preclinical SUD ...

Advancements in clinical RNA therapeutics: Present developments ...

... preclinical or clinical development phases. These aptamers show ... Trial numbers (phase). Non-loaded mRNA. Naked tumor-associated ...

Advancements in clinical RNA therapeutics: Present developments ...

Subsequent to this discovery, extensive preclinical investigations into IVT mRNA laid the foundation for the clinical development of mRNA ...

Preclinical and clinical development of siRNA-based therapeutics.

Therapeutic Potentials of Noncoding RNAs: Targeted Delivery of ncRNAs in Cancer Cells. Yang LiuJun Wang. Medicine. Advances in experimental medicine and ...

The development of lncRNA drugs is key to regulating the treatment ...

PreClinical lncRNA Medicinal: LT-002. The drug LT-002 is a type of lncRNA, which stands for long non-coding RNA. It is ...

The Potential for microRNA Therapeutics and Clinical Research

Keywords: microRNAs, noncoding RNA, epigenetic, ncRNA, preclinical, clinical trials, clinical research. Citation: Hanna J, Hossain GS and ...