Predictive biomarkers for cancer immunotherapy with immune ...

In this review, we deeply analyze the exploration course and research progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy.

Predictive biomarkers of immunotherapy response with ... - Nature

Immune-checkpoint inhibitors show promising effects in the treatment of multiple tumor types. Biomarkers are biological indicators used to ...

A New Biomarker for Response to Checkpoint Inhibitors - NCI

Mismatch repair deficiency is a biomarker for predicting response to cancer immune checkpoint inhibitors ... Biomarker for Cancer Immunotherapy?

Biomarkers for Immunotherapy: Current Developments and ...

These studies collectively suggest that there may be host, tumor, and immune factors that can be used for biomarker development. The importance of the tumor ...

Immunotherapy-related biomarkers: Confirmations and uncertainties

Immune-related adverse events have also been reported with ICIs, ranging from mild to life-threatening, and in some cases leading to tumor hyper-progression ( ...

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

Although monotherapy with PD-1 or PD-L1 agents are typically well tolerated, the risk of immune-related adverse events increases with combination regimens. The ...

Predictive Biomarkers for Immunotherapy in Lung Cancer

Immunotherapy including immune checkpoint inhibitors (ICIs) has become the backbone of treatment for most lung cancers with advanced or ...

Immunotherapy Biomarkers - Cancer Research Institute

Pre-Existing Immune Responses ... The presence of CD8+ “killer” T cells within and around tumors—a biomarker sometimes referred to as the Immunoscore—has been ...

Predictive Biomarkers for Checkpoint Inhibitor Immune-Related ...

Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment of cancer, but they cause immune-related adverse events (irAEs) in around 40% of ...

Progress and Challenges of Predictive Biomarkers for Immune ...

This cycle can be divided into three major steps: release of cancer antigens and their presentation to T cells, then T cells get activated and reach the tumor ...

Therapeutic targets and biomarkers of tumor immunotherapy - Nature

Antibodies against CTLA-4 and PD-1, as well as CAR-T-cell therapy, represent promising approaches in which certain components of the immune ...

Biomarkers for Predicting Response to Immunotherapy with Immune ...

Less widely investigated predictive biomarkers for immunotherapy include tumor-infiltrating CD8+ lymphocytes and specific gene signatures. Despite being widely ...

The role of PD-L1 expression as a predictive biomarker

On this basis, PD-L1 protein expression on tumor or immune cells emerged as the first potential predictive biomarker for sensitivity to immune checkpoint ...

Prognostic and Predictive Biomarkers in the Era of Immunotherapy ...

The therapeutic algorithm of lung cancer has recently been revolutionized by the emergence of immune checkpoint inhibitors. However, an objective and ...

Biomarkers and computational models for predicting efficacy to ...

Numerous studies have shown that immune checkpoint inhibitor (ICI) immunotherapy has great potential as a cancer treatment, leading to significant clinical ...

Predictive Biomarkers for Immunotherapy in Lung Cancer

Similarly, tumor mutational burden (TMB) has multiple technical issues as a predictive biomarker for ICIs. Now, ongoing research on tumor- and host immune- ...

Biomarkers in Precision Cancer Immunotherapy: Promise and ...

Because of possible correlations between immune regression in neuroblastoma and melanoma, immune-predictive score was validated among 10 ...

SY01-5 Predictive biomarkers for cancer immunotherapy based on ...

These data indicate the significance of comprehensive analyses of the mechanism of immune cell infiltration in cancer patients when identifying therapeutic ...

Predictive biomarkers for cancer immunotherapy with immune ...

Although the clinical development of immune checkpoint inhibitors (ICIs) therapy has ushered in a new era of anti- tumor therapy, with sustained responses and ...

Predictive biomarkers of immunotherapy for non-small cell lung cancer

The knowledge of numerous factors that come into play in the cancer-immunity cycle provide a wide range of potential therapeutic targets, including monoclonal ...