Prevalence of Germline Variants in Prostate Cancer and ...

Prevalence of Germline Variants in Prostate Cancer and ... - PubMed

Current NCCN guidelines and Gleason scores cannot reliably stratify patients with prostate cancer for the presence or absence of pathogenic ...

This cross-sectional study of 3607 men with a personal history of prostate cancer found that 620 (17.2%) had a pathogenic germline variant.

Prevalence of Germline Variants in Prostate Cancer and ...

This cross-sectional study of 3607 men with a personal history of prostate cancer found that 620 (17.2%) had a pathogenic germline variant, of ...

Prevalence of Germline Variants in Prostate Cancer and ...

Positive variants in HOXB13, a gene associated only with prostate cancer risk, were identified in 30 patients (4.5%). DNA mismatch repair variants with ...

Comparable Germline Variant Rates Seen Across Racial Groups in ...

Among patients with metastatic prostate cancer in 3 prospectively ascertained, diverse cohorts, the real-world rates of DNA repair ...

Prevalence and Spectrum of Pathogenic Germline Variants in ...

Proportions of patients with germline pathogenic variants differed by cancer subgroup, with the highest in BC (14.8%), followed by CRC (9.2%), ...

Germline Genetics of Prostate Cancer: Prevalence of Risk Variants ...

In this review, we discuss germline variants associated with inherited predisposition, prostate cancer risk and outcomes.

Impact of germline DNA repair gene variants on prognosis and ...

CHEK2 and ATM were the most frequently mutated genes in our cohort (both at 2.7%), both with slightly higher prevalence than previously reported ...

Prevalence of Germline Variants in Prostate Cancer and ... - UroToday

In the dataset, 17% of patients had germline variants and 30% of those were BRCA1/BRCA2. In addition, 4.5% of these patients had HOXB13 which is ...

Germline genetic variants in men with prostate cancer and one or ...

In total, 11 of 102 patients (10.8%) were found to have pathogenic or likely pathogenic mutations in cancer-predisposing genes. The majority of ...

Germline testing and genetic counselling in prostate cancer - Nature

Population risk for developing prostate cancer is 11%, whereas men with specific genetic mutations (pathogenic or probable pathogenic variants) ...

Prostate Cancer: Germline Mutations in BRCA1 and BRCA2

The Association of germline mutations in BRCA1 and BRCA2 genes can cause breast cancer in almost 35% of women and 9% of men. Carriers of these ...

Patterns and Frequency of Pathogenic Germline Variants Among ...

Background: Germline genetic testing (GGT) has significant implications in the management of patients with prostate cancer (PCa).

Genetic testing and management of prostate cancer patients with ...

Approximately 5% of localized and up to 12% of metastatic prostate cancer (PCa) patients carry pathogenic germline variants, with BRCA2 being ...

Ethnic disparities among men with prostate cancer undergoing ...

P/LP germline variants are prevalent in men with prostate cancer. AAC, Hispanic, and API men with prostate cancer are under-represented in studies of germline ...

Germline Testing in Prostate Cancer: When and Who to Test

Germline mutations in DNA repair genes, such as BRCA1/2, contribute to hereditary prostate cancer risk and are present in up to 11.8% of men ...

Detection of Germline Variants in Patients With Localized and ...

Five hundred five patients underwent germline testing and had clinical data available. Rates of P/LP germline variants were 7.6% (20/264) in ...

Genetics of Prostate Cancer (PDQ®) - NCI

[50] The cumulative lifetime risk of prostate cancer (to age 80 y) was 30.0% (95% CI, 16.54%–41.30%; P = .07) in carriers of MMR gene pathogenic ...

Inherited DNA-Repair Gene Mutations in Men with Metastatic ...

In our multicenter study, the incidence of germline mutations in genes mediating DNA-repair processes among men with metastatic prostate cancer ...

Mainstream germline genetic testing in men with metastatic prostate ...

A pathogenic germline variant in BRCA2 was most prevalent in almost all studies, with a prevalence between 1.0 to 8.6% [4, 18]. The prevalence ...