Probing Conformational Dynamics by Protein Contact Networks

Protein contact networks (PCNs) have been used for the study of protein structure and function for the past decade. In PCNs, each amino acid is considered ...

(PDF) Probing Conformational Dynamics by Protein Contact Networks

The core decomposition of networks has long been used in systems biology but never utilized in protein structure networks to identify a tolerant ...

Probing Conformational Dynamics by Protein Contact Networks ...

Protein contact networks (PCNs) have been used for the study of protein structure and function for the past decade. In PCNs, each amino acid is considered ...

Probing Conformational Dynamics by Protein Contact Networks

Probing Conformational Dynamics by Protein Contact Networks: Comparison with NMR Relaxation Studies and Molecular Dynamics Simulations.

Probing the structural dynamics of proteins and nucleic acids ... - NCBI

By measuring conformational changes induced in a molecule by forces applied by optical tweezers, new insight has been gained into the ...

Probing Activation and Conformational Dynamics of the Vesicle ...

G-protein-coupled receptors (GPCRs) are structurally flexible membrane proteins that mediate a host of physiological responses to ...

Probing protein structural dynamics at the single-molecule level by ...

Conformational heterogeneity, such as multiple weakly populated conformational states, is challenging to resolve from ensemble methods such as ...

Distinct Roles for Conformational Dynamics in Protein-ligand ...

Conformational dynamics has an established role in enzyme catalysis, but its contribution to ligand binding and specificity is largely unexplored.

Conformational dynamics and kinetics of protein interactions by ...

Complex formations may lead to changes at the interaction surface, including changes in electron density due to differences in hydrophobicity and the proximity ...

Probing microscopic conformational dynamics in folding reactions ...

Here we review single-molecule fluorescence and force spectroscopy measurements of transition-path properties, including the time taken to traverse the paths.

Multiscale complex network of protein conformational fluctuations in ...

Conformational dynamics of proteins can be interpreted as itinerant motions as the protein traverses from one state to another on a complex network in ...

Discovering and Perturbing the Conformational Dynamics of Enzymes

Figure 1. Figure 1. Protein dynamics occur at different time scales. (a) Motions on the picosecond to nanosecond scale involve small changes in ...

Probing Protein Conformational Variation by Inter-Metal Distance ...

We also investigated the conformational dynamics of the same protein by X-ray scattering, neutron scattering, and MD simulation. Different biophysical, ...

Probing the Flexibility of Large Conformational Changes in Protein ...

In the absence of alternate conformations, various approximation schemes based on contact analysis, such as guassian network models [7] and FIRST [8], have been ...

Probing conformational landscapes and mechanisms of allosteric ...

In the current study, multiscale simulation approaches and dynamic network methods are employed to examine the dynamic and energetic details of ...

Surveying the Side-Chain Network Approach to Protein Structure ...

Our objective is to review network-based analyses to elucidate such variations, especially in the context of subtle conformational changes. We present technical ...

Using chirality to probe the conformational dynamics and assembly ...

They allow focus to be placed solely on the question of how changes in amino acid side-chain orientation, and the resultant alterations in ...

Probing the Conformational Dynamics of Protein-DNA Complexes ...

We hypothesize that time-averaged differences in conformation dynamics can be resolved through their equilibrium hydration properties. The rationale for our ...

Probing Single-Molecule Protein Conformational Dynamics

Protein conformational fluctuations and dynamics, often complex and associated with inhomogeneities, play a crucial role in biomolecular ...

Kinase Activity: Probing conformational dynamics to understand ...

Protein kinases are enzymes that act as molecular switches for signaling pathways in cells. Most kinases have an “on”- ...